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The cellular response to the genotoxic insult : the question of threshold for genotoxic carcinogens

Author: Helmut Greim; Richard J Albertini; Royal Society of Chemistry (Great Britain)
Publisher: Cambridge, UK : RSC Publishing, ©2012.
Series: Issues in toxicology, 13.
Edition/Format:   Print book : EnglishView all editions and formats
Database:WorldCat
Summary:

This book considers the exposure levels at which genotoxins pose a risk and describes the cellular mechanisms used against them.

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Document Type: Book
All Authors / Contributors: Helmut Greim; Richard J Albertini; Royal Society of Chemistry (Great Britain)
ISBN: 9781849731775 1849731772
OCLC Number: 796268235
Description: xiv, 319 pages : illustrations ; 25 cm.
Contents: Introduction: The rationale for thresholds for genotoxic carcinogens; Part 1. Threshold effects observed in experimental studies: Mechanisms responsible for the chromosome and gene mutations driving carcinogenesis: implications for dose-response characteristics of mutagenic carcinogens; Dose-effect relationships of DANN-reactive liver carcinogens; DNA alkylation and repair after EEMS exposure: Where do the thresholds for mutagenic/clastogenic effects arise? Part 2. Metabolic inactivation of genotoxic reactants: Enzymatic detoxification of endogenously produced mutagenic carcinogens maintaining cellular homeostasis; Phase 2 detoxifying enzymes and anti-oxygen defense mechanisms in the inactivation of genotoxic carcinogens; Part 3. DNA repair: Consequences and Repair of oxidative DNA damage; The plasticity of DNA damage response during cell differentiation: pathways and consequences; Tumor suppressor protein-mediated regulation of base excision repair in response to DNA damage; Part 4. Apoptosis: Survival and death strategies in cells exposed to genotoxin; Different modes of cell death induced by DNA damage; Transcriptional inhibition by DNA damage as a trigger of cell death; Part 5. Epigenetic mechanisms: The interplay between epigenetics and Gap junctionional intercellular communication; Index
Series Title: Issues in toxicology, 13.
Responsibility: edited by Helmut Greim, Richard J. Albertini.

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"This book will, therefore, make excellent and stimula ting reading for all toxicologists (from the student to the most senior toxicologist} in academia, industry and government as well as scienlists Read more...

 
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