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Cellular senescence and tumor suppression

Author: Peter D Adams; John M Sedivy
Publisher: New York : Springer, ©2010.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Leonard Hayflick and colleagues coined the term "cellular senescence" to describe the inevitable and irreversible proliferation arrest of primary human cells in culture. Specifically, Hayflick and coworkers reported the phenomenon of replicative senescence in primary human fibroblasts, showing that these cells can proliferate in vitro for about 55 population doublings before their proliferative capacity succumbs to  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Cellular senescence and tumor suppression.
New York : Springer, ©2010
(DLC) 2009933096
(OCoLC)642277643
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Peter D Adams; John M Sedivy
ISBN: 9781441910752 1441910751
OCLC Number: 663096724
Description: 1 online resource (xiii, 272 pages) : illustrations
Contents: Telomere biology and biochemistry --
Short telomere-driven senescence --
Oncogene-induced senescence --
Stress-induced senescence --
Modulation of senescence by extracellular growth factors --
The senescent phenotype and its evolution --
Chromatin structure in senescent cells --
A comparison of senescence in mouse and human cells --
Tumor suppression --
Tissue aging --
Senescence as a potential therapeutic tool.
Responsibility: Peter D. Adams, John M. Sedivy, editors.

Abstract:

This book covers the latest findings in the link between cellular senescence and cancer including telemores and senescence signals, the senescent phenotype, and the physiological effects of  Read more...

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