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Central D₁ dopamine receptors

Author: Menek Goldstein; Kjell Fuxe; Irving Tabachnick
Publisher: New York : Plenum Press, ©1988.
Series: Advances in experimental medicine and biology, v. 235.
Edition/Format:   Print book : Conference publication : EnglishView all editions and formats
Summary:
The development of a selective D1 dopamine (DA) receptor antagonist SCH 23390 stimulated a number of studies on the functions mediated by central DA receptor subtypes. It was generally assumed that the central D1 DA receptor is a molecular entity whose function awaits further discovery. The papers presented in this volume clearly show that this is no longer the case and that D1 DA receptors have many behavioral  Read more...
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Genre/Form: Congresses
Conference papers and proceedings
Additional Physical Format: Online version:
Symposium on Central D₁ Dopamine Receptors (1986 : New York, N.Y.)
Central D₁ dopamine receptors.
New York : Plenum Press, ©1988
(OCoLC)1029840817
Material Type: Conference publication, Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Menek Goldstein; Kjell Fuxe; Irving Tabachnick
ISBN: 030642925X 9780306429255
OCLC Number: 17954419
Notes: "Based on the proceedings of the Symposium on Central D₁ dopamine Receptors, held December 5, 1986, in New York, New York"--Title page verso.
Description: viii, 183 pages : illustrations ; 26 cm.
Contents: Dopamine-Regulated Protein Phosphorylation in the Basal Ganglia.- The D-1 Dopamine Receptor.- Biochemical Properties of D-1 and D-2 Dopamine Receptors.- Biochemical and Functional Characterization of Central Dopamine Receptors.- Dopamine D-1 and D-2 Receptor Selectivities of Agonists and Antagonists.- DARPP-32 as a Marker for D-1 Dopaminoceptive Cells in the Rat Brain: Prenatal Development and Presence in Glial Elements (Tanycytes) in the Basal Hypothalamus.- Studies on Central D-1 Receptors Role in Volume Transmission, Neuroendocrine Regulation and Release of Noradrenaline.- N-Ethoxycarbonyl-2-Ethoxy-1,2-Dihydroquinoline (EEDQ): A New Tool to Probe CNS Receptor Function.- Pharmacological and Behavioral Effects of D-1 Dopamine Antagonists.- Neurophysiological Examination of the Role of D-1 Dopamine Receptors in the Regulation of Neuronal Activity in the Basal Ganglia.- Diminished D-2 Dopamine Receptor Function and the Emergence of Repetitive Jaw Movements.- D-1 Dopamine Receptors and Arousal.
Series Title: Advances in experimental medicine and biology, v. 235.
Responsibility: edited by Menek Goldstein, Kjell Fuxe, and Irving Tabachnick.

Abstract:

The development of a selective D1 dopamine (DA) receptor antagonist SCH 23390 stimulated a number of studies on the functions mediated by central DA receptor subtypes. It was generally assumed that the central D1 DA receptor is a molecular entity whose function awaits further discovery. The papers presented in this volume clearly show that this is no longer the case and that D1 DA receptors have many behavioral fuctions which might be altered in pathological states. A number of papers have recognized the interdependence of the regulatory functions of the D1 DA receptors with D2 and other receptor, proteins, and vice versa. The biochemical, pharmacological and morphological characterization of the D1 and D2 DA receptor binding proteins, as well as of DARPP-32, illustrates the complex interactions between various macromolecules. Procedures described for the purification of the D1 and D2 DA receptor subtypes are fundamental for future studies on the mechanisms involved in the coupling of the receptor proteins with signal transuding systems. Several studies in this volume show that D1 DA receptors have behavioral functions and that they are often similar to the responses mediated by D2 DA receptors, but in some instances reflect divergent neuronal activity of both systems. The knowledge of the physiology and biochemistry of the central DA receptor subtypes could lead to the development of a new generation of drugs which ameliorate some mental and neurological dysfunctions without producing severe undesirable side effects. This volume is based on papers presented at the Symposium on Central D1 Dopamine Receptors held at the Chemist's Club in New York City on December 5, 1986. The editors would like to thank Dr. Frank Bullock of Schering Corporation and Dr. John Vogel.

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