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Centrosomes in development and disease

Author: Erich A Nigg
Publisher: Weinheim : Wiley-VCH, ©2004.
Edition/Format:   Book : EnglishView all editions and formats
Database:WorldCat
Summary:
Located in the center of the animal cell, the centrosome has long been considered a mystery. Nigg (cell biology, University of Geneva, Switzerland) summarizes current knowledge on the structure, function, and evolution of centrosomes and related microtubule-organizing centers. Reflecting recent discoveries and ongoing research, the book emphasizes the role of centrosomes in development and disease, with a particular  Read more...
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Genre/Form: Aufsatzsammlung
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Erich A Nigg
ISBN: 3527309802 9783527309801
OCLC Number: 56538940
Description: xlii, 431 p., 20 p. of plates : ill. (some col.) ; 25 cm.
Contents: Early studies on centrioles and centrosomes --
Tubulin superfamily --
Microtubule nucleation --
The budding yeast spindle pole body: a centrosome analog --
Dissection of basal body and centriole function in the unicellular green alga chlamydomonas reinhardtii --
The centrosome in evolution --
A proteomic approach to the inventory of the human centrosome --
The role of the centrosome in cell cycle progression --
Centrosome duplication and its regulation in the higher animal cell --
A synergy of technologies: using green fluorescent protein tagging and laser microsurgery to study centrosome function and duplication in vertebrates --
Centrosome regulation in response to environmental and genotoxic stress --
The C. elegans centrosome during early embryonic development. Centrosomes in a developing organism: lessons from drosophila --
Centrosome inheritance during human fertilization and "therapeutic" cloning: reproductive and developmental diseases and disorders caused by centrosome dysfunction --
Microtubule organizing centers in polarized epithelial cells --
Centrosome anomalies in cancer: from early observations to animal models --
Radiation therapy and centrosome anomalies in pancreatic cancer --
Human papillomavirus infection and centrosome anomalies in cervical cancer --
Manipulation of centrosomes and the microtubule cytoskeleton during infection by intracellular pathogens --
Basal bodies and microtubule organization in pathogenic protozoa.
Responsibility: edited by Erich A. Nigg.
More information:

Abstract:

Located in the center of the animal cell, the centrosome has long been considered a mystery. Nigg (cell biology, University of Geneva, Switzerland) summarizes current knowledge on the structure, function, and evolution of centrosomes and related microtubule-organizing centers. Reflecting recent discoveries and ongoing research, the book emphasizes the role of centrosomes in development and disease, with a particular focus on cancer. Chapters are grouped in sections on microtubule organization and dynamics, the integration of centrosome and chromosome cycles, the centrosome in development and tissue architecture, and centrosomes in disease. B&w and color images and illustrations are included.

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Linked Data


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