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Centrosomes in development and disease

Author: Erich A Nigg; John Wiley & Sons.
Publisher: Weinheim : Wiley-VCH, ©2004.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Discovered over a century ago, the centrosome is the major microtubule organizing center of the animal cell. It is a tiny organelle of surprising structural complexity. Over the last few years our understanding of the structure and composition of centrosomes has greatly advanced, and the demonstration of frequent centrosome anomalies in most common human tumors has sparked additional interest in the role of this  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Centrosomes in development and disease.
Weinheim : Wiley-VCH, ©2004
(DLC) 2004303455
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Erich A Nigg; John Wiley & Sons.
ISBN: 3527309802 9783527309801 3527603808 9783527603800 3527604340 9783527604340
OCLC Number: 85820510
Description: 1 online resource (xxi, 431 pages) : illustrations (some color)
Contents: Early studies on centrioles and centrosomes --
Tubulin superfamily --
Microtubule nucleation --
The budding yeast spindle pole body: a centrosome analog --
Dissection of basal body and centriole function in the unicellular green alga chlamydomonas reinhardtii --
The centrosome in evolution --
A proteomic approach to the inventory of the human centrosome --
The role of the centrosome in cell cycle progression --
Centrosome duplication and its regulation in the higher animal cell --
A synergy of technologies: using green fluorescent protein tagging and laser microsurgery to study centrosome function and duplication in vertebrates --
Centrosome regulation in response to environmental and genotoxic stress --
The C. elegans centrosome during early embryonic development. Centrosomes in a developing organism: lessons from drosophila --
Centrosome inheritance during human fertilization and "therapeutic" cloning: reproductive and developmental diseases and disorders caused by centrosome dysfunction --
Microtubule organizing centers in polarized epithelial cells --
Centrosome anomalies in cancer: from early observations to animal models --
Radiation therapy and centrosome anomalies in pancreatic cancer --
Human papillomavirus infection and centrosome anomalies in cervical cancer --
Manipulation of centrosomes and the microtubule cytoskeleton during infection by intracellular pathogens --
Basal bodies and microtubule organization in pathogenic protozoa.
Responsibility: edited by Erich A. Nigg.
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Abstract:

Summarizes the understanding of the structure, function and evolution of microtubule organizing centres, primarily centrosomes. This book emphasizes the role of these organelles in development and  Read more...

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"The chapters are well written, understandable, and provide clearexplanations of difficult concepts...highly recommended foracademic and special libraries with related research areas."(E-STREAMS, Read more...

 
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