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Checkpoint controls and cancer. Volume 1, Reviews and model systems

Author: Axel H Schönthal
Publisher: Totowa, N.J. : Human Press, ©2004.
Series: Methods in molecular biology (Clifton, N.J.), v. 281.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Intracellular checkpoint controls constitute a network of signal transduction pathways that protect cells from external stresses and internal errors by means of cell cycle arrest, DNA repair, or apoptosis. Failure of this machinery can lead to embryonic death, genetic diseases, and cancer. In Checkpoint Controls and Cancer, Volume 1: Reviews and Model Systems, Axel H. Schn̲thal, PhD, marshals a prestigious panel of  Read more...
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Genre/Form: Electronic books
Laboratory manuals
Laboratory Manuals
Review
Additional Physical Format: Print version:
Checkpoint controls and cancer. Volume 1, Reviews and model systems.
Totowa, N.J. : Human Press, ©2004
(DLC) 2004040578
(OCoLC)54046830
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Axel H Schönthal
ISBN: 1592597882 9781592597888 9781588292148 1588292142
OCLC Number: 61264745
Language Note: English.
Description: 1 online resource (1 volume) : illustrations.
Contents: G1 and S-phase checkpoints, chromosome instability, and cancer / H. Nojima --
Analyzing the G2/M checkpoint / G.R. Stark and W.R. Taylor --
Analyzing the spindle checkpoint in yeast and frogs / P.T. Stukenberg and D.J. Burke --
Cell cycle checkpoint control mechanisms that can be disrupted in cancer / B.C. Dash and W.S. El-Deiry --
Establishment of a cell-free system to study the activation of chk2 / X. Xu and D.F. Stern --
Analyzing checkpoint controls in human skin / S. Pavey and B.G. Gabrielli --
Generation and analysis of brca1 conditional knockout mice / C.X. Deng and X. Xu --
Analysis of cell cycle progression and genomic integrity in early lethal knockouts / E.J. Brown --
Xenopus cell-free extracts to study the DNA damage response / V. Costanzo, K. Robertson and J. Gautier --
A Xenopus cell-free system for analysis of the chfr ubiquitin ligase involved in control of mitotic entry / D. Kang, J. Wong and G. Fang --
Control of mitotic entry after DNA damage in drosophila / B. Jaklevic, A. Purdy and T.T. Su --
Methods for analyzing checkpoint responses in caenorhabditis elegans / A. Gartner, A.J. MacQueen and A.M. Villeneuve --
Assaying the spindle checkpoint in the budding yeast saccharomyces cerevisiae / C.M. Yellman and D.J. Burke --
Purification and analysis of checkpoint protein complexes from saccharomyces cerevisiae / C.M. Green and N.F. Lowndes.
Series Title: Methods in molecular biology (Clifton, N.J.), v. 281.
Other Titles: Reviews and model systems
Responsibility: edited by Axel H. Schönthal.

Abstract:

In response to any of these assaults on the integrity of the genome, the activation of the network of checkpoint control pathways can lead to diverse cellular responses, such as cell cycle arrest,  Read more...

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