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Chemical Carcinogenesis

Author: Claudio Nicolini
Publisher: Boston, MA : Springer US, 1982.
Series: NATO advanced study institutes series., Series A,, Life sciences ;, 52.
Edition/Format:   eBook : Document : EnglishView all editions and formats
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Claudio Nicolini
ISBN: 9781468443349 1468443348
OCLC Number: 851811857
Description: 1 online resource (xi, 492 pages).
Contents: Section I: Chemicals as Carcinogens --
Chemical Carcinogenesis by Polycyclic Aromatic Hydrocarbons --
N-Substituted Aromatic Compounds --
Metabolic Epoxidation of Aflatoxin B1 and Its Metabolites: Patterns of DNA Adduct Formation and Removal in Relation to Biological Effects --
The Problematic Use of Chemical Class Controls in Absence of Information on the Underlying Mechanism --
Discussion --
Section II: DNA Adducts --
DNA Lesions: Nature and Genesis --
DNA Alkaline Elution: Physical Basis of the Elution Process and Validation of this Method as a Screeing Procedure to Identify Chemical Carcinogens --
DNA Fragmentation: Its Predictivity as a Short Term Test --
Measurement of Viscous and Elastic Components of Native DNA Fiber Following Carcinogen Administration --
Initiation of Experimental Liver Carcinogenesis by Chemicals: Are the Carcinogen Altered Hepatocytes Stimulated to Grow into Foci by Different Selection Procedures Identical? --
Influence of DNA Conformation on DNA Methylation and the Direct Binding of N-Methyl-N-Nitroso-N1-Nitro-Guanidine --
Genotoxic Effects of Drugs: Experimental Findings Concerning Some Chemical Families of Therapeutic Relevance --
Discussion --
Section III: Chemicals as Promotors --
Phenobarbital and Other Liver Tumor Promotors --
Molecular Mechanisms of Multistage Carcinogenesis --
Alterations of Liver Architecture in Mice Treated with Anabolic Androgens and Diethylnitrosamine --
Discussion --
Section IV: Carcinogenesis as Multistep Process --
Some Critical Consideration Concerning the Sequential Analysis of Carcinogenesis with Chemicals --
Benign and Malignant Tumor Induction in Mouse Skin --
Progress in the Study of In Vitro Neoplastic Transformation --
Pulse-Carcinogenesis by Ethylnitrosourea in the Developing Rat Nervous System: Molecular and Cellular Mechanisms --
Chromatin, Nuclei and Water: Alterations and Mechanisms for Chemically-Induced Carcinogenesic --
The Cytoskeleton: An Intermediate in the Expression of the Transformed Phenotype in Malignant Cells --
Discussion --
List of Participants --
Contributor Index.
Series Title: NATO advanced study institutes series., Series A,, Life sciences ;, 52.
Responsibility: edited by Claudio Nicolini.

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