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The chemistry and pharmacology of Taxol and its derivatives

Author: Vittorio Farina
Publisher: Amsterdam ; New York : Elsevier, 1995.
Series: Pharmacochemistry library, v. 22.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Taxol®, a naturally occurring diterpenoid is one of the most exciting antitumor drugs available today. Its current indications (refractory ovarian and metastatic breast cancer) may soon be expanded since the drug is showing activity against lung and head-and-neck cancers. The book opens with a review of the naturally occurring taxoids, a chapter which is not a comprehensive list of all taxoids isolated to date, but  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Chemistry and pharmacology of Taxol and its derivatives.
Amsterdam ; New York : Elsevier, 1995
(DLC) 95018110
(OCoLC)32430830
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Vittorio Farina
ISBN: 9780444817716 0444817719 9780080544991 0080544991
OCLC Number: 162588157
Description: 1 online resource (ix, 339 pages) : illustrations.
Contents: Naturally occurring taxoids ; The structural elucidation of taxoids / G. Appendino --
Paclitaxel (Taxol®) formulation and prodrug / D. Vyas --
Metabolism and pharmacology of taxoids / M. Wright [and others] --
Paclitaxel (Taxol®) chemistry and structure activity relationships / S.H. Chen, V. Farina --
The chemistry of the Taxol® side chain : synthesis, modifications and conformational studies / J. Kant --
The biochemical pharmacology of Taxol® and mechanisms of resistance / T. MacDonald, L. Landino.
Series Title: Pharmacochemistry library, v. 22.
Responsibility: edited by Vittorio Farina.

Abstract:

Taxol®, a naturally occurring diterpenoid is one of the most exciting antitumor drugs available today. Its current indications (refractory ovarian and metastatic breast cancer) may soon be expanded since the drug is showing activity against lung and head-and-neck cancers. The book opens with a review of the naturally occurring taxoids, a chapter which is not a comprehensive list of all taxoids isolated to date, but attempts a systematic approact to describing the different classes of taxoids, with particular reference to all skeletal types and the various functionality patterns. Biosynthetic studies are also discussed, as well as some of the basic chemistry and common functionalities of taxoidic skeleton. Structural identification of taxoids, mostly by spectroscopic means; the formulation of taxanes; the metabolism and pharmacokinetics of Taxol® are also discussed, as are the chemistry of taxanes in relation to SAR studies; SAR aspects of the phenylisoserine side chain; and the mode of action of the taxanes and the mechanisms of resistance. The book is therefore written for medical chemists, in order to stimulate further research in this area and to provide the reader with the necessary background information to start a research program in the area.

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