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Chemosensitivity. Volume 2, In vivo models, imaging, and molecular regulators

Author: Rosalyn D Blumenthal
Publisher: Totowa, N.J. : Humana Press, ©2005.
Series: Methods in molecular medicine, 111.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Chemosensitivity testing is an ex vivo means of determining or enhancing the cytotoxic and/or cytostatic, or apoptosis-inducing effects of anticancer drugs. In Chemosensitivity, leading researchers and physicians working in academia and biotech companies describe their best laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in  Read more...
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Genre/Form: Electronic books
Laboratory manuals
Additional Physical Format: Print version:
Chemosensitivity. Volume 2, In vivo models, imaging, and molecular regulators.
Totowa, N.J. : Humana Press, ©2005
(DLC) 2004012494
(OCoLC)55534931
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Rosalyn D Blumenthal
ISBN: 1592598897 9781592598892 1588295869 9781588295866
OCLC Number: 61114296
Description: 1 online resource (1 volume) : illustrations.
Contents: v. 2. In vitro micronucleus technique to predict chemosensitivity / M. Fenech --
Cell cycle and drug sensitivity / A. Kazi and Q.P. Dou --
TUNEL assay as a measure of chemotherapy-induced apoptosis / R. Wieder --
Apoptosis assessment by the DNA diffusion assay / N.P. Singh --
PARP cleavage and caspase activity to assess chemosensitivity / A.C. Bharti [and others] --
Diphenylamine assay of DNA fragmentation for chemosensitivity testing / C. Gercel-Taylor --
Immunodetecting members of the Bcl-2 family of proteins / R.B. Lock and K.M. Murphy --
Correlation of telomerase activity and telomere length to chemosensitivity / Y. Kiyozuka --
Application of silicon sensor technologies to tumor tissue in vitro: Detection of metabolic correlates of chemosensitivity / P. Mestres-Ventura [and others] --
Overview of tumor cell chemoresistance mechanisms / L. Gatti and F. Zunino --
Flow cytometric monitoring of fluorescent drug retention and efflux / A. Krishan and R.M. Hamelik --
Flow cytometric measurement of functional and phenotypic P-glycoprotein / M. Pallis and E. Das-Gupta --
Measurement of ceramide and sphingolipid metabolism in tumors: Potential modulation of chemotherapy / D.E. Modrak --
Gene expression profiling to characterize anticancer drug sensitivity / J.K. Breaux and G. Los --
Identifying genes related to chemosensitivity using support vector machine / L. Bao --
Genetic manipulation of yeast to identify genes involved in regulation of chemosensitivity / G.L. Beretta and P. Perego --
Real-time RT-PCR (TaqMan) of tumor mRNA to predict sensitivity of specimens to 5-fluorouracil / T. Kubota --
Use of proteomics to study chemosensitivity / J. Poland [and others] --
Clinically relevant metastatic breast cancer models to study chemosensitivity / L.S. Kim and J.E. Price --
Orthotopic metastatic (metamouse) models for discovery and development of novel chemotherapy / R.M. Hoffman --
Preclinical testing of antileukemic drugs using an in vivo model of systemic disease / R.B. Lock [and others] --
Assessing growth and response to therapy in murine tumor models / C.P. Reynolds [and others] --
Evaluation of chemosensitivity of micrometastases with green fluorescent protein gene-tagged tumor models in mice / H. Nakanishi [and others] --
99mTc-Annexin A5 uptake and imaging to monitor chemosensitivity / T.Z. Belhocine and F.G. Blankenberg --
Magnetic resonance imaging of tumor response to chemotherapy / R. Mazurchuk and J.A. Spernyak --
Metabolic monitoring of chemosensitivity with 18FDG PET / G. Jerusalem and T.Z. Belhocine.
Series Title: Methods in molecular medicine, 111.
Other Titles: In vivo models, imaging, and molecular regulators
Responsibility: edited by Rosalyn D. Blumenthal.

Abstract:

Chemosensitivity testing is an ex vivo means of determining or enhancing the cytotoxic and/or cytostatic, or apoptosis-inducing effects of anticancer drugs. In Chemosensitivity, leading researchers and physicians working in academia and biotech companies describe their best laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Volume 2: In Vivo Models, Imaging, and Molecular Regulators contains today's best protocols for classifying tumors into response categories and for customizing therapy to individuals. These techniques allow measurements of DNA damage, apoptotic cell death, and the molecular and cellular regulators of cytotoxicity, as well as in vivo animal modeling of chemosensitivity. Highlights include genomic and proteomic approaches to assess chemosensivity, in vivo imaging approaches to assess early response to therapy, and methods to statistically analyze data from in vivo therapy. The protocols follow the successful Methods in Molecular Medicine™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. The authors also provide guidance on how best to analyze the data derived from the protocols. A companion volume, Volume 1: In Vitro Assays contains in vitro and in vivo techniques to identify which new agents or combination of agents are effective for each type of tumor. Cutting-edge and highly practical, the two volumes of Chemosensitivity provide a comprehensive collection of readily reproducible techniques for the in vitro and in vivo screening of new agents and a set of proven approaches to understand mechanistically why certain cancer cell lines (in vitro) of tumors (in vivo) are more or less sensitive to a particular agent.

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