skip to content
Chitosan and its derivatives as promising drug delivery carriers Preview this item
ClosePreview this item
Checking...

Chitosan and its derivatives as promising drug delivery carriers

Author: M Prabaharan
Publisher: New York, N.Y. : ASME : Momentum Press, 2012.
Series: Biomedical & nanomedical technologies.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Chitosan, a natural based polymer obtained by alkaline deacetylation of chitin, is non-toxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for the development of conventional and novel drug delivery systems. Recently, there has been a growing interest in the chemical modification of chitosan in order to improve its solubility and widen its applications. Chemical modification of  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

 

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Prabaharan, M.
Chitosan and its derivatives as promising drug delivery carriers.
New York, NY : ASME : Co-published by Momentum Press, LLC, ©2012
(OCoLC)815383528
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: M Prabaharan
ISBN: 9781606504130 1606504134
OCLC Number: 825344985
Description: 1 online resource (76 pages) : illustrations.
Contents: 1. Introduction --
2. Sources of chitosan --
3. Advantages of chitosan as drug delivery systems --
3.1 Biocompatibility and biodegradability --
3.2 pH sensitivity --
3.3 Controlled drug release properties --
3.4 Mucoadhesive properties --
3.5 Permeation enhancing properties --
3.6 Transfection enhancing properties --
3.7 Gelling properties --
3.8 Colon targeting properties --
3.9 Ease of chemical modification --
4. Chitosan-based drug delivery systems --
4.1 Chitosan microspheres --
4.1.1 Covalently crosslinked particles --
4.1.2 Ionically crosslinked particles --
4.2 Chemically modified chitosan --
4.2.1 Amphiphilic chitosan derivatives --
4.2.2 N-(aminoalkyl) chitosan --
4.2.3 Succinyl, quateraminated and octanoyl chitosan --
4.2.4 Carboxymethyl chitosan --
4.2.5 Mitomycin-C conjugated N-succinyl-chitosan --
4.2.6 Thiolated chitosans --
4.2.7 Phosphorylated chitosan --
4.2.8 Chitosan-based polyelectrolyte complexes --
4.3 Graft Copolymerized chitosan --
4.3.1 Chitosan-graft-poly(acrylic acid) --
4.3.2 Chitosan-graft-poly(acrylamide) --
4.3.3 Chitosan-graft-poly(methyl methacrylate) --
4.3.4 Chitosan-graft-2-hydroxyethyl methacrylate --
4.3.5 Chitosan-graft-poly(vinyl alcohol) --
4.3.6 Chitosan-graft-poly(ethylene glycol) --
4.3.7 Cyclodextrin grafted chitosan --
4.3.8 Chitosan-graft-b-glycerophosphate --
4.4 Chitosan-based stimuli-responsive hydrogels --
4.5 Chitosan-ligand conjugates for active target drug delivery --
4.5.1 Chitosan-sugar conjugates --
4.5.2 Chitosan-folate conjugates --
4.5.3 Chitosan-protein conjugates --
5. Conclusions --
References.
Series Title: Biomedical & nanomedical technologies.
Responsibility: M. Prabaharan.
More information:

Abstract:

Chitosan, a natural based polymer obtained by alkaline deacetylation of chitin, is non-toxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for the development of conventional and novel drug delivery systems. Recently, there has been a growing interest in the chemical modification of chitosan in order to improve its solubility and widen its applications. Chemical modification of chitosan is useful for the association of bioactive molecules to the polymer and controlling the drug release profile. Chemical modification will introduce desired properties and enlarge the field of the potential applications of chitosan with the choice of various types of side chains. In this monograph, recent studies on the various types of chitosan microspheres are discussed from the viewpoint of drug delivery applications. Moreover, different types of chitosan derivatives developed as controlled drug delivery carriers and their preparation methods are discussed in detail. The modifications discussed here include amphiphilic chitosan derivatives, N-(aminoalkyl) chitosan, carboxymethyl chitosan, thiolated chitosans, phosphorylated chitosan, etc. Special emphasis has been given to the development of chitosan-based polyelectrolyte complexes, graft copolymerized chitosan and chitosan-based stimuli-responsive hydrogels as drug delivery carriers. The reviewed studies lead to the conclusion that chitosan derivatives are promising materials for the controlled delivery of various types of therapeutic agents.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/825344985> # Chitosan and its derivatives as promising drug delivery carriers
    a schema:CreativeWork, schema:Book, schema:MediaObject ;
    library:oclcnum "825344985" ;
    library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/1175682862#Place/new_york_n_y> ; # New York, N.Y.
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/nyu> ;
    schema:about <http://id.loc.gov/authorities/subjects/sh2010002681> ; # Chitosan--Biotechnology
    schema:about <http://id.worldcat.org/fast/1070574> ; # Polymeric drug delivery systems
    schema:about <http://id.worldcat.org/fast/858001> ; # Chitosan--Biotechnology
    schema:about <http://experiment.worldcat.org/entity/work/data/1175682862#Thing/biomedical_and_materials_engineers> ; # Biomedical and materials engineers
    schema:about <http://dewey.info/class/610.28/e23/> ;
    schema:bookFormat schema:EBook ;
    schema:creator <http://viaf.org/viaf/86288577> ; # M. Prabaharan
    schema:datePublished "2012" ;
    schema:description "1. Introduction -- 2. Sources of chitosan -- 3. Advantages of chitosan as drug delivery systems -- 3.1 Biocompatibility and biodegradability -- 3.2 pH sensitivity -- 3.3 Controlled drug release properties -- 3.4 Mucoadhesive properties -- 3.5 Permeation enhancing properties -- 3.6 Transfection enhancing properties -- 3.7 Gelling properties -- 3.8 Colon targeting properties -- 3.9 Ease of chemical modification -- 4. Chitosan-based drug delivery systems -- 4.1 Chitosan microspheres -- 4.1.1 Covalently crosslinked particles -- 4.1.2 Ionically crosslinked particles -- 4.2 Chemically modified chitosan -- 4.2.1 Amphiphilic chitosan derivatives -- 4.2.2 N-(aminoalkyl) chitosan -- 4.2.3 Succinyl, quateraminated and octanoyl chitosan -- 4.2.4 Carboxymethyl chitosan -- 4.2.5 Mitomycin-C conjugated N-succinyl-chitosan -- 4.2.6 Thiolated chitosans -- 4.2.7 Phosphorylated chitosan -- 4.2.8 Chitosan-based polyelectrolyte complexes -- 4.3 Graft Copolymerized chitosan -- 4.3.1 Chitosan-graft-poly(acrylic acid) -- 4.3.2 Chitosan-graft-poly(acrylamide) -- 4.3.3 Chitosan-graft-poly(methyl methacrylate) -- 4.3.4 Chitosan-graft-2-hydroxyethyl methacrylate -- 4.3.5 Chitosan-graft-poly(vinyl alcohol) -- 4.3.6 Chitosan-graft-poly(ethylene glycol) -- 4.3.7 Cyclodextrin grafted chitosan -- 4.3.8 Chitosan-graft-b-glycerophosphate -- 4.4 Chitosan-based stimuli-responsive hydrogels -- 4.5 Chitosan-ligand conjugates for active target drug delivery -- 4.5.1 Chitosan-sugar conjugates -- 4.5.2 Chitosan-folate conjugates -- 4.5.3 Chitosan-protein conjugates -- 5. Conclusions -- References."@en ;
    schema:description "Chitosan, a natural based polymer obtained by alkaline deacetylation of chitin, is non-toxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for the development of conventional and novel drug delivery systems. Recently, there has been a growing interest in the chemical modification of chitosan in order to improve its solubility and widen its applications. Chemical modification of chitosan is useful for the association of bioactive molecules to the polymer and controlling the drug release profile. Chemical modification will introduce desired properties and enlarge the field of the potential applications of chitosan with the choice of various types of side chains. In this monograph, recent studies on the various types of chitosan microspheres are discussed from the viewpoint of drug delivery applications. Moreover, different types of chitosan derivatives developed as controlled drug delivery carriers and their preparation methods are discussed in detail. The modifications discussed here include amphiphilic chitosan derivatives, N-(aminoalkyl) chitosan, carboxymethyl chitosan, thiolated chitosans, phosphorylated chitosan, etc. Special emphasis has been given to the development of chitosan-based polyelectrolyte complexes, graft copolymerized chitosan and chitosan-based stimuli-responsive hydrogels as drug delivery carriers. The reviewed studies lead to the conclusion that chitosan derivatives are promising materials for the controlled delivery of various types of therapeutic agents."@en ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/1175682862> ;
    schema:genre "Electronic books"@en ;
    schema:inLanguage "en" ;
    schema:isPartOf <http://experiment.worldcat.org/entity/work/data/1175682862#Series/biomedical_&_nanomedical_technologies> ; # Biomedical & nanomedical technologies.
    schema:isPartOf <http://experiment.worldcat.org/entity/work/data/1175682862#Series/biomedical_&_nanomedical_technologies_concise_monograph_series> ; # Biomedical & nanomedical technologies - concise monograph series
    schema:isSimilarTo <http://www.worldcat.org/oclc/815383528> ;
    schema:name "Chitosan and its derivatives as promising drug delivery carriers"@en ;
    schema:productID "825344985" ;
    schema:publication <http://www.worldcat.org/title/-/oclc/825344985#PublicationEvent/new_york_n_y_asme_momentum_press_2012> ;
    schema:publisher <http://experiment.worldcat.org/entity/work/data/1175682862#Agent/asme> ; # ASME
    schema:publisher <http://experiment.worldcat.org/entity/work/data/1175682862#Agent/momentum_press> ; # Momentum Press
    schema:url <http://ebooks.asmedigitalcollection.asme.org/book.aspx?bookid=637> ;
    schema:url <http://site.ebrary.com/id/10641505> ;
    schema:url <http://ebookcentral.proquest.com/lib/ucm/detail.action?docID=1144316> ;
    schema:url <http://www.myilibrary.com?id=824717> ;
    schema:url <http://ezaccess.libraries.psu.edu/login?url=http://portal.igpublish.com/iglibrary/search/MPB0000067.html> ;
    schema:url <http://public.ebookcentral.proquest.com/choice/publicfullrecord.aspx?p=1144316> ;
    schema:url <http://ezproxy.lib.ryerson.ca/login?url=http://ebooks.asmedigitalcollection.asme.org/book.aspx?bookid=637> ;
    schema:url <http://dx.doi.org/10.1115/1.860052> ;
    schema:url <http://site.ebrary.com/id/10649186> ;
    schema:workExample <http://dx.doi.org/10.1115/1.860052> ;
    schema:workExample <http://worldcat.org/isbn/9781606504130> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/825344985> ;
    .


Related Entities

<http://ebooks.asmedigitalcollection.asme.org/book.aspx?bookid=637>
    rdfs:comment "to access electronic resource" ;
    .

<http://experiment.worldcat.org/entity/work/data/1175682862#Agent/momentum_press> # Momentum Press
    a bgn:Agent ;
    schema:name "Momentum Press" ;
    .

<http://experiment.worldcat.org/entity/work/data/1175682862#Place/new_york_n_y> # New York, N.Y.
    a schema:Place ;
    schema:name "New York, N.Y." ;
    .

<http://experiment.worldcat.org/entity/work/data/1175682862#Series/biomedical_&_nanomedical_technologies> # Biomedical & nanomedical technologies.
    a bgn:PublicationSeries ;
    schema:hasPart <http://www.worldcat.org/oclc/825344985> ; # Chitosan and its derivatives as promising drug delivery carriers
    schema:name "Biomedical & nanomedical technologies." ;
    .

<http://experiment.worldcat.org/entity/work/data/1175682862#Series/biomedical_&_nanomedical_technologies_concise_monograph_series> # Biomedical & nanomedical technologies - concise monograph series
    a bgn:PublicationSeries ;
    schema:hasPart <http://www.worldcat.org/oclc/825344985> ; # Chitosan and its derivatives as promising drug delivery carriers
    schema:name "Biomedical & nanomedical technologies - concise monograph series" ;
    .

<http://experiment.worldcat.org/entity/work/data/1175682862#Thing/biomedical_and_materials_engineers> # Biomedical and materials engineers
    a schema:Thing ;
    schema:name "Biomedical and materials engineers" ;
    .

<http://id.loc.gov/authorities/subjects/sh2010002681> # Chitosan--Biotechnology
    a schema:Intangible ;
    schema:name "Chitosan--Biotechnology"@en ;
    .

<http://id.worldcat.org/fast/1070574> # Polymeric drug delivery systems
    a schema:Intangible ;
    schema:name "Polymeric drug delivery systems"@en ;
    .

<http://id.worldcat.org/fast/858001> # Chitosan--Biotechnology
    a schema:Intangible ;
    schema:name "Chitosan--Biotechnology"@en ;
    .

<http://viaf.org/viaf/86288577> # M. Prabaharan
    a schema:Person ;
    schema:familyName "Prabaharan" ;
    schema:givenName "M." ;
    schema:name "M. Prabaharan" ;
    .

<http://worldcat.org/isbn/9781606504130>
    a schema:ProductModel ;
    schema:isbn "1606504134" ;
    schema:isbn "9781606504130" ;
    .

<http://www.worldcat.org/oclc/815383528>
    a schema:CreativeWork ;
    rdfs:label "Chitosan and its derivatives as promising drug delivery carriers." ;
    schema:description "Print version:" ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/825344985> ; # Chitosan and its derivatives as promising drug delivery carriers
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.