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  E-mail Message: I thought you might be interested in this item at http://www.worldcat.org/oclc/116488973 Title: Chromatophoromas in a pine snake. Publisher: ISBN/ISSN: 0893-5785 OCLC:116488973

  
  

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Chromatophoromas in a pine snake.

Author:	ER Jacobson; W Ferris; JT Bagnara; WO Iverson
Edition/Format:	Article : English
Publication:	Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, 1989 Jan-Feb; 2(1): 26-33
Database:	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Summary:	Iridophoroma and melanophoroma were diagnosed in an adult male pine snake. Light microscopic examination of irregularly thickened white and black portions of abnormal scales demonstrated two distinctive populations of pigment-containing cells. Pigment cells within abnormal-appearing white scales had needle-shaped granules that were dark amber in color while black portions were composed of pigment cells typical of melanophores, with dark black, round granules. Both populations of cells showed junctional activity, and clusters of both neoplastic pigment cell types were found in adjoining areas of the epidermis. By electron microscopy, the pigment cell with amber-colored granules contained reflecting platelet profiles typical of iridophores while pigment cells with dark round granules contained melanosomes. At a junctional area between abnormal white and black scales, mosaic chromatophores containing reflecting platelet profiles and melanosomes were observed. At 1 1/2 years following initial diagnosis, the snake died and neoplastic iridophores were found at multiple visceral sites; there was no evidence of metastases of melanophores to any organ. The two pigment cell tumors are believed to have developed from either stem cells destined to become iridophores and melanophores or from prexisting iridophores and melanophores in the dermis.  Read more...
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