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Clinical pharmacology during pregnancy

Author: Donald R Mattison
Publisher: Amsterdam : Elsevier, 2013.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Clinical Pharmacology During Pregnancy is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals directly involved in the care of women during pregnancy. This book focuses on the impact of pregnancy on drug disposition and also includes coverage of treatments for diseases of specific body systems, as well as essential content on dosing and efficacy. Written in a clear and  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Mattison, Donald.
Clinical Pharmacology During Pregnancy.
Burlington : Elsevier Science, ©2013
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Donald R Mattison
ISBN: 9780123860088 0123860083
OCLC Number: 820853643
Description: 1 online resource (xxi, 471 pages)
Contents: Front Cover; Clinical Pharmacology During Pregnancy; Copyright; Contents; Contributors; 1 --
Introduction; References; 2 --
Physiologic Changes During Pregnancy; 2.1 Physiologic changes during pregnancy; 2.2 Cardiovascular system; 2.3 Respiratory system; 2.4 Renal system; 2.5 Gastrointestinal system; 2.6 Hematologic and coagulation systems; 2.7 Endocrine system; 2.8 Summary; References; 3 --
Impact of Pregnancy on Maternal Pharmacokinetics of Medications; 3.1 Introduction; 3.2 Effects of pregnancy on pharmacokinetic parameters; 3.3 Summary; References; 4 --
Medications and the Breastfeeding Mother. 4.1 Medication use by the breastfeeding mother ;4.2 Clinical pharmacology of drug transfer into breast milk; 4.3 During delivery; 4.4 General anesthesia; 4.5 Epidural anesthesia; 4.6 Galactogogues; 4.7 Immediate postpartum period; 4.8 Pain; 4.9 Methadone; 4.10 Resumption of pre-pregnancy medications; 4.11 Psycho- and neurotropic drugs; 4.12 Drugs not to give to the nursing mother postpartum; 4.13 Oral contraceptives (OCPs); 4.14 Summary; 4.15 Where to find information; References; 5 --
Fetal Drug Therapy; 5.1 Introduction; 5.2 Indications for fetal therapy; 5.3 Strategies to achieve fetal drug therapy. 5.4 Special considerations; Acknowledgments; References; 6 --
Treating the Placenta: an Evolving Therapeutic Concept; 6.1 Introduction; 6.2 The placenta as the therapeutic target: the past; 6.3 The placenta: therapeutic targets; 6.4 The placenta as a therapeutic target today; 6.5 The placenta as a therapeutic target in the future; Conclusions; References; 7 --
What is Sufficient Evidence to Justify a Multicenter Phase 3 Randomized Controlled Trial in Obstetrics?; 7.1 Introduction; 7.2 Evidence, equipoise, and the ethical considerations in deciding whether to conduct a trial. 7.3 Why are failure rates so high for pregnancy drug trials compared to other therapeutic areas? 7.4 Role of phase 2 trials; 7.5 How to improve success rates; 7.6 Learning from experience --
the example of antioxidants and preeclampsia; Conclusions and recommendations; References; 8 --
Ethics of Clinical Pharmacology Research in Pregnancy; References; Questions for further discussion; 9 --
Pharmacogenomics in Pregnancy; 9.1 Pharmacogenomics; 9.2 Genetics and polymorphisms; 9.3 Genes that influence pharmacokinetic variability; 9.4 The current state of pharmacogenetic testing. 9.5 Potential therapeutic areas for pharmacogenomics in pregnancy; 9.6 Study designs and approaches to pharmacogenetics trials; References; 10 --
Analgesics and Anti-Inflammatory, General and Local Anesthetics and Muscle Relaxants; 10.1 Introduction; 10.2 General anesthesia; 10.3 Inhalational anesthetics; 10.4 Intravenous anesthetics; 10.5 Neuromuscular blocking agents; 10.6 Regional anesthesia; 10.7 Summary; References; 11 --
The Management of Asthma During Pregnancy; 11.1Introduction; 11.2 Effect of pregnancy on the course of asthma; 11.3 Effect of asthma on pregnancy; 11.4 Asthma management.
Responsibility: edited by Donald R. Mattison.

Abstract:

Suitable for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals directly involved in the care of women during pregnancy, this book focuses on the impact of  Read more...

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"This medications references is intended for medical and health professionals involved in the care of pregnant women...A companion website features case studies, slides, bulleted summaries, and Read more...

 
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