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Clinical trials in neurology

Author: Roberto J Guiloff
Publisher: London ; New York : Springer, ©2001.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

Clinical Trials in Neurology comprehensively tackles the methodology and design of clinical trials in neurological disease. A diseases section tackles specific aspects of disorders, focusing on the  Read more...

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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Roberto J Guiloff
ISBN: 1852332395 9781852332396
OCLC Number: 43523135
Description: xvii, 542 pages : illustrations ; 28 cm
Contents: Ch. 1. Ethical considerations --
Ch. 2. Assessment measures and clinical scales --
Ch. 3. Ethics, outcome variables and clinical scales: the clinician's point of view --
Ch. 4. The Cochrane collaboration reviews in neurology --
Ch. 5. Drug development stages --
Ch. 6. Drug regulatory requirements in the United Kingdom and Europe --
Ch. 7. Drug regulatory requirements in the United States --
Ch. 8. Quality control and data monitoring: a guide to good clinical practice --
Ch. 9. Statistical issues in clinical trials in neurology --
Ch. 10. Analysis of results: statistical principles --
Ch. 11. Survival analysis --
Ch. 12. The intention-to-treat principle for clinical trials --
Ch. 13. Statistical analysis of repeated-measures data with drop-outs --
Ch. 14. The role of meta-analyses in clinical research: uses and limitations --
Ch. 15. Outcome variables in dementia trials: conceptual and practical issues --
Ch. 16. Dementia: trial design and experience with large multicentre trials --
Ch. 17. Cerebrovascular disease: basic designs, sample sizes and pitfalls. Ch. 18. Clinical trials in stroke prevention in North America --
Ch. 19. Cerebrovascular disease: experience within large multicentre trials --
Ch. 20. Epilepsy: ethics, outcome variables and clinical scales --
Ch. 21. Epilepsy: basic designs, sample sizes and experience with large multicentre trials --
Ch. 22. Headache: ethics, outcome variables and clinical studies --
Ch. 23. Headache: basic trials designs, sample sizes and pitfalls --
Ch. 24. Headache: experience with large multicenter trials in the treatment of migraine attacks --
Ch. 25. Parkinson's disease: outcome variables and clinical scales --
Ch. 26. Parkinson's disease: a review of drug trials --
Ch. 27. Parkinson's disease: experience with large multicentre trials --
Ch. 28. Tremor: clinical measurement of impairment, disability and handicap --
Ch. 29. Tremor: natural behaviour, trial design and physiological outcome measures --
Ch. 30. Multiple sclerosis: ethics, outcome variables and clinical scales --
Ch. 31. Multiple sclerosis: study design, sample sizes and pitfalls --
Ch. 32. Multiple sclerosis: experience with large clinical trials --
Ch. 33. Motor neurone disease: ethics, outcome variables and clinical scales --
Ch. 34. Motor neurone disease: basic designs, sample sizes and pitfalls --
Ch. 35. Motor neurone disease: experience with large multicentre trials --
Ch. 36. Peripheral neuropathies: controlled clinical trials --
Ch. 37. Peripheral neuropathies: experience with large multicentre trials --
Ch. 38. Disorders of the neuromuscular junction: outcome measures and clinical scales --
Ch. 39. Myasthenia gravis: basic designs, sample sizes and pitfalls --
Ch. 40. Myopathies: ethics, outcome variables and clinical scales --
Ch. 41. Myopathies: basic designs, sample sizes and pitfalls.
Responsibility: Roberto J. Guiloff (ed).
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"This much needed book is a gem. If you are involved in a clinical trial make sure you and all your collaborators have read it, before the trial commences...This book provides the information the Read more...

 
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