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Clinically Relevant Resistance in Cancer Chemotherapy

Author: Borje Andersson; David Murray
Publisher: Boston, MA : Springer US, 2002.
Series: Cancer treatment and research, 112.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
The present volume reviews clinically relevant aspects of the pharmacokinetics of commonly used anticancer agents as well as mechanisms of cellular/experimental resistance to such agents. This extends to technological advances that enable high-throughput studies of genetic polymorphisms, which has opened up new avenues to the study of drug resistance and to the individualization of chemotherapy in order to decrease  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Borje Andersson; David Murray
ISBN: 9781461511731 1461511739
OCLC Number: 852788095
Description: 1 online resource (xx, 380 pages).
Contents: List of contributors. Preface. 1. Tumor physiology and resistance to chemotherapy: repopulation and drug penetration; A.J. Davis, I.F. Tannock. 2. The role of membrane transporters in cellular resistance to anticancer nucleoside drugs; M.L. Clarke, et al. 3. MDR and MRP gene families as cellular determinant factors for resistance to clinical anticancer agents; L. Deng, et al. 4. The glutathione system in alkylator resistance; D. Hamilton, et al. 5. The role of signal transduction pathways in drug and radiation resistance; S. Grant, et al. 6. Mechanisms of repair of interstrand crosslinks in DNA; R.J. Legerski, C. Richie. 7. DNA repair in resistance to bifunctional alkylating and platinating agents; D. Murray. 8. Leukemic cell insensitivity to cyclophosphamide and other oxazaphosphorines mediated by aldehyde dehydrogenase(s); N.E. Sladek. 9. Mechanisms of resistance against cyclophosphamide and ifosfamide: can they be overcome without sacrificing selectivity? S.M. Ludeman, M.P. Gamcsik. 10. Cellular mechanisms of cyclophosphamide resistance: model studies in human medulloblastoma cell lines; H.S. Friedman, et al. 11. Model studies of cyclophosphamide resistance in human myeloid leukemia; B.S. Andersson, D. Murray. 12. Mechanisms of drug resistance in AML; M. Andreeff, M. Konopleva. 13. Biochemical and molecular mechanisms of cisplatin resistance; Z.H. Siddik. 14. Modification of radiosensitivity following chemotherapy exposure: potential implications for combined-modality therapy; R.A. Britten. 15. Clinical pharmacology of melphalan and itsimplications for clinical resistance to anticancer agents; R.B. Jones. 16. Pharmacological considerations of primary alkylators; J.S. McCune, J.T. Slattery. 17. Genomic approaches to clinical drug resistance; S. Damaraju, et al. Index.
Series Title: Cancer treatment and research, 112.
Responsibility: edited by Borje Andersson, David Murray.

Abstract:

Over the last several decades, the introduction of new chemotherapeutic drugs and drug combinations has resulted in increased long- term remission rates in several important tumor types.  Read more...

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