skip to content
Colonic motility : from bench side to bedside Preview this item
ClosePreview this item
Checking...

Colonic motility : from bench side to bedside

Author: Sushil K Sarna
Publisher: San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, ©2010.
Series: Colloquium series on integrated systems physiology, # 11.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Three distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mixing/turning over. Infrequently occurring giant migrating contractions (GMCs) produce mass movements. Tonic contractions aid RPCs in their motor function. The spatiotemporal patterns of these contractions differ markedly. The amplitude and distance of  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

 

Find a copy online

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Sushil K Sarna
ISBN: 9781615041510 1615041516 1615041508 9781615041503
OCLC Number: 759473342
Notes: Series from website.
Description: 1 online resource (1 online resource (xiii, 143 pages)) : illustrations, digital file.
Contents: [1]. Introduction --
Motility requirements of different organs --
How gut contractions mix/turn over and propel digesta --
Types of gut contractions --
Rhythmic phasic contractions --
Ultrapropulsive contractions --
Tonic contractions --
Descending inhibition --
Composition of three types of contractions in gut organs --
Functions and spatiotemporal characteristics of colonic contractions --
Colonic rhythmic phasic contractions --
Colonic giant migrating contractions. [2]. Regulatory mechanisms --
Rhythmic phasic contractions --
Short-duration rhythmic phasic contractions --
Excitation-contraction coupling --
Electromechanical coupling --
Pharmacomechanical coupling --
Excitation-inhibition coupling --
Cellular origin and relaxation oscillator characteristics of slow waves --
Regulation of propagation of short-duration RPCs --
Types of enteric neurons and their functional significance --
Motor neurons --
Interneurons --
Intrinsic sensory neurons --
Long-duration RPCs --
Giant migrating contractions --
Tonic contractions --
Excitation-transcription coupling --
Enteric reflexes. [3]. Colonic motility in health --
Methods of recording human colonic motor activity and analysis of data --
Correlation between colonic contractions and propulsion --
Diurnal variations of human colonic motor activity --
Gastrocolonic reflex/response --
Defecation --
What causes random generation of GMCs --
Anorectal motor activity. [4]. Colonic motility dysfunction --
GMCs and visceral pain of gut origin --
Irritable bowel syndrome --
Diarrhea-predominant IBS --
Colonic motor dysfunction in IBS-D patients --
Constipation-predominant IBS, slow-transit constipation, idiopathic constipation, and constipation due to pelvic floor dysfunction --
Colonic motor dysfunction in IBS-C, slow-transit constipation, idiopathic constipation, and pelvic floor dysfunction patients --
Alternating constipation/diarrhea IBS --
Postinfectious IBS --
Cellular and molecular mechanisms of IBS and other types of constipation --
Smooth muscle and enteric neuronal dysfunction --
Impaired gastrocolonic response --
Abdominal cramping/pain --
Stress --
Early-life trauma and IBS --
Impaired enteric reflexes --
Impaired smooth muscle excitation-contraction coupling in slow-transit constipation --
Role of ICCs --
Role of alterations in the expression of neuropeptides in the myenteric plexus and structural damage to enteric neurons and smooth muscle cells --
Epigenetic dysregulation --
Posttransitional histone modifications --
DNA methylation --
Genetics. [5]. Inflammatory bowel disease --
Motility dysfunction in colonic inflammation --
Visceral hypersensitivity in IBD --
Cellular and molecular mechanisms --
Smooth muscle dysfunction --
Enteric neuronal dysfunction --
Diverticular disease --
Colonic motor dysfunction in diverticular disease patients --
Cellular and molecular mechanisms --
References.
Series Title: Colloquium series on integrated systems physiology, # 11.
Responsibility: Sushil K. Sarna.

Abstract:

Three distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mixing/turning over. Infrequently  Read more...

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/759473342> # Colonic motility : from bench side to bedside
    a schema:MediaObject, schema:CreativeWork, schema:Book ;
   library:oclcnum "759473342" ;
   library:placeOfPublication <http://id.loc.gov/vocabulary/countries/cau> ;
   library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/771549297#Place/san_rafael_calif_1537_fourth_street_san_rafael_ca_94901_usa> ; # San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA)
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Thing/volume_transmission> ; # Volume transmission
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Thing/excitation_contraction_coupling> ; # Excitation-contraction coupling
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Thing/smooth_muscle> ; # Smooth muscle
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Thing/descending_inhibition> ; # Descending inhibition
   schema:about <http://id.loc.gov/authorities/subjects/sh85028548> ; # Colon (Anatomy)--Motility
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Thing/enteric_nervous_system> ; # Enteric nervous system
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Thing/visceral_hypersensitivity> ; # Visceral hypersensitivity
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Thing/slow_waves> ; # Slow waves
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Thing/diverticular_disease> ; # Diverticular disease
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Thing/peristaltic_reflex> ; # Peristaltic reflex
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Thing/diarrhea> ; # Diarrhea
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Topic/medical_nutrition> ; # MEDICAL--Nutrition
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Thing/enteric_neurons> ; # Enteric neurons
   schema:about <http://id.worldcat.org/fast/868423> ; # Colon (Anatomy)--Motility
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Thing/irritable_bowel_syndrome> ; # Irritable bowel syndrome
   schema:about <http://dewey.info/class/612.36/e22/> ;
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Thing/defecation> ; # Defecation
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Thing/motility_disorders> ; # Motility disorders
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Thing/inflammatory_bowel_disease> ; # Inflammatory bowel disease
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Thing/icc> ; # ICC
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Thing/excitation_inhibition_coupling> ; # Excitation-inhibition coupling
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Thing/synaptic_transmission> ; # Synaptic transmission
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Topic/colon> ; # Colon
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Topic/gastrointestinal_motility> ; # Gastrointestinal Motility
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Thing/abdominal_pain> ; # Abdominal pain
   schema:about <http://experiment.worldcat.org/entity/work/data/771549297#Thing/constipation> ; # Constipation
   schema:bookFormat schema:EBook ;
   schema:copyrightYear "2010" ;
   schema:creator <http://viaf.org/viaf/170592503> ; # Sushil K. Sarna
   schema:datePublished "2010" ;
   schema:description "Three distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mixing/turning over. Infrequently occurring giant migrating contractions (GMCs) produce mass movements. Tonic contractions aid RPCs in their motor function. The spatiotemporal patterns of these contractions differ markedly. The amplitude and distance of propagation of a GMC are several-fold larger than those of an RPC. The enteric neurons and smooth muscle cells are the core regulators of all three types of contractions. The regulation of contractions by these mechanisms is modifiable by extrinsic factors: CNS, autonomic neurons, hormones, inflammatory mediators, and stress mediators. Only the GMCs produce descending inhibition, which accommodates the large bolus being propelled without increasing muscle tone. The strong compression of the colon wall generates afferent signals that are below nociceptive threshold in healthy subjects. However, these signals become nociceptive; if the amplitudes of GMCs increase, afferent nerves become hypersensitive, or descending inhibition is impaired. The GMCs also provide the force for rapid propulsion of feces and descending inhibition to relax the internal anal sphincter during defecation. The dysregulation of GMCs is a major factor in colonic motility disorders: irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and diverticular disease (DD). Frequent mass movements by GMCs cause diarrhea in diarrhea predominant IBS, IBD, and DD, while a decrease in the frequency of GMCs causes constipation. The GMCs generate the afferent signals for intermittent short-lived episodes of abdominal cramping in these disorders. Epigenetic dysregulation due to adverse events in early life is one of the major factors in generating the symptoms of IBS in adulthood."@en ;
   schema:description "[1]. Introduction -- Motility requirements of different organs -- How gut contractions mix/turn over and propel digesta -- Types of gut contractions -- Rhythmic phasic contractions -- Ultrapropulsive contractions -- Tonic contractions -- Descending inhibition -- Composition of three types of contractions in gut organs -- Functions and spatiotemporal characteristics of colonic contractions -- Colonic rhythmic phasic contractions -- Colonic giant migrating contractions."@en ;
   schema:exampleOfWork <http://worldcat.org/entity/work/id/771549297> ;
   schema:genre "Electronic books"@en ;
   schema:inLanguage "en" ;
   schema:isPartOf <http://worldcat.org/issn/2154-5626> ; # Integrated systems physiology, from molecule to function to disease,
   schema:isPartOf <http://experiment.worldcat.org/entity/work/data/771549297#Series/colloquium_series_on_integrated_systems_physiology> ; # Colloquium series on integrated systems physiology ;
   schema:name "Colonic motility : from bench side to bedside"@en ;
   schema:productID "759473342" ;
   schema:publication <http://www.worldcat.org/title/-/oclc/759473342#PublicationEvent/san_rafael_calif_1537_fourth_street_san_rafael_ca_94901_usa_morgan_&_claypool_2010> ;
   schema:publisher <http://experiment.worldcat.org/entity/work/data/771549297#Agent/morgan_&_claypool> ; # Morgan & Claypool
   schema:url <http://dx.doi.org/10.4199/C00020ED1V01Y201011ISP011> ;
   schema:url <http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=440499> ;
   schema:url <http://public.eblib.com/choice/publicfullrecord.aspx?p=881320_0> ;
   schema:workExample <http://dx.doi.org/10.4199/C00020ED1V01Y201011lSP011> ;
   schema:workExample <http://worldcat.org/isbn/9781615041503> ;
   schema:workExample <http://worldcat.org/isbn/9781615041510> ;
   wdrs:describedby <http://www.worldcat.org/title/-/oclc/759473342> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/771549297#Agent/morgan_&_claypool> # Morgan & Claypool
    a bgn:Agent ;
   schema:name "Morgan & Claypool" ;
    .

<http://experiment.worldcat.org/entity/work/data/771549297#Place/san_rafael_calif_1537_fourth_street_san_rafael_ca_94901_usa> # San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA)
    a schema:Place ;
   schema:name "San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA)" ;
    .

<http://experiment.worldcat.org/entity/work/data/771549297#Series/colloquium_series_on_integrated_systems_physiology> # Colloquium series on integrated systems physiology ;
    a bgn:PublicationSeries ;
   schema:hasPart <http://www.worldcat.org/oclc/759473342> ; # Colonic motility : from bench side to bedside
   schema:name "Colloquium series on integrated systems physiology ;" ;
    .

<http://experiment.worldcat.org/entity/work/data/771549297#Thing/descending_inhibition> # Descending inhibition
    a schema:Thing ;
   schema:name "Descending inhibition" ;
    .

<http://experiment.worldcat.org/entity/work/data/771549297#Thing/diverticular_disease> # Diverticular disease
    a schema:Thing ;
   schema:name "Diverticular disease" ;
    .

<http://experiment.worldcat.org/entity/work/data/771549297#Thing/enteric_nervous_system> # Enteric nervous system
    a schema:Thing ;
   schema:name "Enteric nervous system" ;
    .

<http://experiment.worldcat.org/entity/work/data/771549297#Thing/excitation_contraction_coupling> # Excitation-contraction coupling
    a schema:Thing ;
   schema:name "Excitation-contraction coupling" ;
    .

<http://experiment.worldcat.org/entity/work/data/771549297#Thing/excitation_inhibition_coupling> # Excitation-inhibition coupling
    a schema:Thing ;
   schema:name "Excitation-inhibition coupling" ;
    .

<http://experiment.worldcat.org/entity/work/data/771549297#Thing/inflammatory_bowel_disease> # Inflammatory bowel disease
    a schema:Thing ;
   schema:name "Inflammatory bowel disease" ;
    .

<http://experiment.worldcat.org/entity/work/data/771549297#Thing/irritable_bowel_syndrome> # Irritable bowel syndrome
    a schema:Thing ;
   schema:name "Irritable bowel syndrome" ;
    .

<http://experiment.worldcat.org/entity/work/data/771549297#Thing/motility_disorders> # Motility disorders
    a schema:Thing ;
   schema:name "Motility disorders" ;
    .

<http://experiment.worldcat.org/entity/work/data/771549297#Thing/peristaltic_reflex> # Peristaltic reflex
    a schema:Thing ;
   schema:name "Peristaltic reflex" ;
    .

<http://experiment.worldcat.org/entity/work/data/771549297#Thing/synaptic_transmission> # Synaptic transmission
    a schema:Thing ;
   schema:name "Synaptic transmission" ;
    .

<http://experiment.worldcat.org/entity/work/data/771549297#Thing/visceral_hypersensitivity> # Visceral hypersensitivity
    a schema:Thing ;
   schema:name "Visceral hypersensitivity" ;
    .

<http://experiment.worldcat.org/entity/work/data/771549297#Thing/volume_transmission> # Volume transmission
    a schema:Thing ;
   schema:name "Volume transmission" ;
    .

<http://experiment.worldcat.org/entity/work/data/771549297#Topic/gastrointestinal_motility> # Gastrointestinal Motility
    a schema:Intangible ;
   schema:name "Gastrointestinal Motility"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/771549297#Topic/medical_nutrition> # MEDICAL--Nutrition
    a schema:Intangible ;
   schema:name "MEDICAL--Nutrition"@en ;
    .

<http://id.loc.gov/authorities/subjects/sh85028548> # Colon (Anatomy)--Motility
    a schema:Intangible ;
   schema:name "Colon (Anatomy)--Motility"@en ;
    .

<http://id.worldcat.org/fast/868423> # Colon (Anatomy)--Motility
    a schema:Intangible ;
   schema:name "Colon (Anatomy)--Motility"@en ;
    .

<http://viaf.org/viaf/170592503> # Sushil K. Sarna
    a schema:Person ;
   schema:familyName "Sarna" ;
   schema:givenName "Sushil K." ;
   schema:name "Sushil K. Sarna" ;
    .

<http://worldcat.org/isbn/9781615041503>
    a schema:ProductModel ;
   schema:isbn "1615041508" ;
   schema:isbn "9781615041503" ;
    .

<http://worldcat.org/isbn/9781615041510>
    a schema:ProductModel ;
   schema:isbn "1615041516" ;
   schema:isbn "9781615041510" ;
    .

<http://worldcat.org/issn/2154-5626> # Integrated systems physiology, from molecule to function to disease,
    a bgn:PublicationSeries ;
   schema:hasPart <http://www.worldcat.org/oclc/759473342> ; # Colonic motility : from bench side to bedside
   schema:issn "2154-5626" ;
   schema:name "Integrated systems physiology, from molecule to function to disease," ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.