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Colonic motility : from bench side to bedside

Author: Sushil K Sarna
Publisher: San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, ©2010.
Series: Colloquium series on integrated systems physiology, # 11.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Three distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mixing/turning over. Infrequently occurring giant migrating contractions (GMCs) produce mass movements. Tonic contractions aid RPCs in their motor function. The spatiotemporal patterns of these contractions differ markedly. The amplitude and distance of  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Sushil K Sarna
ISBN: 9781615041510 1615041516 1615041508 9781615041503
OCLC Number: 759473342
Notes: Series from website.
Description: 1 online resource (1 online resource (xiii, 143 pages)) : illustrations, digital file.
Contents: [1]. Introduction --
Motility requirements of different organs --
How gut contractions mix/turn over and propel digesta --
Types of gut contractions --
Rhythmic phasic contractions --
Ultrapropulsive contractions --
Tonic contractions --
Descending inhibition --
Composition of three types of contractions in gut organs --
Functions and spatiotemporal characteristics of colonic contractions --
Colonic rhythmic phasic contractions --
Colonic giant migrating contractions. [2]. Regulatory mechanisms --
Rhythmic phasic contractions --
Short-duration rhythmic phasic contractions --
Excitation-contraction coupling --
Electromechanical coupling --
Pharmacomechanical coupling --
Excitation-inhibition coupling --
Cellular origin and relaxation oscillator characteristics of slow waves --
Regulation of propagation of short-duration RPCs --
Types of enteric neurons and their functional significance --
Motor neurons --
Interneurons --
Intrinsic sensory neurons --
Long-duration RPCs --
Giant migrating contractions --
Tonic contractions --
Excitation-transcription coupling --
Enteric reflexes. [3]. Colonic motility in health --
Methods of recording human colonic motor activity and analysis of data --
Correlation between colonic contractions and propulsion --
Diurnal variations of human colonic motor activity --
Gastrocolonic reflex/response --
Defecation --
What causes random generation of GMCs --
Anorectal motor activity. [4]. Colonic motility dysfunction --
GMCs and visceral pain of gut origin --
Irritable bowel syndrome --
Diarrhea-predominant IBS --
Colonic motor dysfunction in IBS-D patients --
Constipation-predominant IBS, slow-transit constipation, idiopathic constipation, and constipation due to pelvic floor dysfunction --
Colonic motor dysfunction in IBS-C, slow-transit constipation, idiopathic constipation, and pelvic floor dysfunction patients --
Alternating constipation/diarrhea IBS --
Postinfectious IBS --
Cellular and molecular mechanisms of IBS and other types of constipation --
Smooth muscle and enteric neuronal dysfunction --
Impaired gastrocolonic response --
Abdominal cramping/pain --
Stress --
Early-life trauma and IBS --
Impaired enteric reflexes --
Impaired smooth muscle excitation-contraction coupling in slow-transit constipation --
Role of ICCs --
Role of alterations in the expression of neuropeptides in the myenteric plexus and structural damage to enteric neurons and smooth muscle cells --
Epigenetic dysregulation --
Posttransitional histone modifications --
DNA methylation --
Genetics. [5]. Inflammatory bowel disease --
Motility dysfunction in colonic inflammation --
Visceral hypersensitivity in IBD --
Cellular and molecular mechanisms --
Smooth muscle dysfunction --
Enteric neuronal dysfunction --
Diverticular disease --
Colonic motor dysfunction in diverticular disease patients --
Cellular and molecular mechanisms --
References.
Series Title: Colloquium series on integrated systems physiology, # 11.
Responsibility: Sushil K. Sarna.
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Abstract:

Three distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mixing/turning over. Infrequently  Read more...

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Primary Entity

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