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|Material Type:||Clipart/images/graphics, Internet resource, Videorecording|
|Document Type:||Internet Resource, Computer File, Visual material|
|All Authors / Contributors:||
W F Bodmer
|Notes:||Title from title frames.
Animated audio-visual presentation with synchronized narration.
|Description:||1 streaming video file (53 min.) : digital, mono, SWF file, sound, color.|
|Contents:||Cancer: a somatic evolutionary process --
Colorectal cancer: a good model to study --
Two clear cut familial forms: FAP and HNPCC --
Mutation selection balance for dominants and recessives: application to FAP --
APC gene found by positional cloning --
Loss of heterozygosity proved its role in sporadic cancers --
Selection for mutations in the APC "mutation cluster region" --
HNPCC mismatch repair genes found by candidate guess --
Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence --
Arguments for and against need for genomic instability in cancers --
Epigenetic changes --
Mathematical model of normal and cancerous crypt --
Types of familial cancers: mostly rarer than FAP and HNPCC --
Approaches to studying multifactorial inherited susceptibility --
HLA and disease: the model --
Role of linkage disequilbrium --
Principles of SNP association analysis --
Rare missense variants in the APC gene confer susceptibility --
The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.
|Series Title:||Henry Stewart talks., Biomedical & life sciences collection., Human population genetics : evolution and variation.|