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Colorectal cancer and the rare variant hypothesis

Author: W F Bodmer
Publisher: London : Henry Stewart Talks, 2007.
Series: Henry Stewart talks., Biomedical & life sciences collection., Human population genetics : evolution and variation.
Edition/Format:   eVideo : Clipart/images/graphics : EnglishView all editions and formats
Database:WorldCat
Summary:
Audio-visual presentation : Cancer: a somatic evolutionary process ; Colorectal cancer: a good model to study ; Two clear cut familial forms: FAP and HNPCC ; Mutation selection balance for dominants and recessives: application to FAP ; APC gene found by positional cloning ; Loss of heterozygosity proved its role in sporadic cancers ; Selection for mutations in the APC "mutation cluster region" ; HNPCC mismatch  Read more...
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Details

Material Type: Clipart/images/graphics, Internet resource, Videorecording
Document Type: Internet Resource, Computer File, Visual material
All Authors / Contributors: W F Bodmer
OCLC Number: 310381624
Notes: Title from title frames.
Animated audio-visual presentation with synchronized narration.
Description: 1 streaming video file (53 min.) : digital, mono, SWF file, sound, color.
Details: Mode of access: World Wide Web.; System requirements: Operating System: PC Windows 2000+, Mac OSX+ 3.2. Browser Compatibility: IE6+, Firefox 2+, Opera 9+, Safari 2+ 3.3. Browser settings: enable JavaScript, enable popups from the Henry Stewart Talks site. 3.4. Required Browser Plugins & Viewers: Adobe (Macromedia) Flash Player 7+, Adobe Acrobat Reader 6.0+.
Contents: Cancer: a somatic evolutionary process --
Colorectal cancer: a good model to study --
Two clear cut familial forms: FAP and HNPCC --
Mutation selection balance for dominants and recessives: application to FAP --
APC gene found by positional cloning --
Loss of heterozygosity proved its role in sporadic cancers --
Selection for mutations in the APC "mutation cluster region" --
HNPCC mismatch repair genes found by candidate guess --
Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence --
Arguments for and against need for genomic instability in cancers --
Epigenetic changes --
Mathematical model of normal and cancerous crypt --
Types of familial cancers: mostly rarer than FAP and HNPCC --
Approaches to studying multifactorial inherited susceptibility --
HLA and disease: the model --
Role of linkage disequilbrium --
Principles of SNP association analysis --
Rare missense variants in the APC gene confer susceptibility --
The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.
Series Title: Henry Stewart talks., Biomedical & life sciences collection., Human population genetics : evolution and variation.
Responsibility: Walter Bodmer.
More information:

Abstract:

Audio-visual presentation : Cancer: a somatic evolutionary process ; Colorectal cancer: a good model to study ; Two clear cut familial forms: FAP and HNPCC ; Mutation selection balance for dominants and recessives: application to FAP ; APC gene found by positional cloning ; Loss of heterozygosity proved its role in sporadic cancers ; Selection for mutations in the APC "mutation cluster region" ; HNPCC mismatch repair genes found by candidate guess ; Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence ; Arguments for and against need for genomic instability in cancers ; Epigenetic changes ; Mathematical model of normal and cancerous crypt ; Types of familial cancers: mostly rarer than FAP and HNPCC ; Approaches to studying multifactorial inherited susceptibility ; HLA and disease: the model ; Role of linkage disequilbrium ; Principles of SNP association analysis ; Rare missense variants in the APC gene confer susceptibility ; The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.

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