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Complement regulatory proteins

Author: B Paul Morgan; Claire L Harris
Publisher: San Diego : Academic Press, ©1999.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
From small beginnings in the early 1970s, the study of complement regulatory proteins has grown in the last decade to the point where it dominates the complement field. This growth has been fueled by the discovery of new regulators, the cloning of old and new regulators, the discovery that many of the regulators are structurally and evolutionarily related to each other and the development of recombinant forms for  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Morgan, B. Paul.
Complement regulatory proteins.
San Diego : Academic Press, ©1999
(DLC) 98089879
(OCoLC)41012048
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: B Paul Morgan; Claire L Harris
ISBN: 9780125069656 0125069650 9781429498388 1429498382 0080529569 9780080529561 128103729X 9781281037299
OCLC Number: 162129230
Description: 1 online resource (xiv, 382 pages) : illustrations
Contents: The Complement System: A Brief Overview: --
Introduction. --
Activation of C. --
Physiological Roles of C. --
Involvement of C in Pathology. --
Why a Book on C Regulators? --
Regulation in the Complement System: --
Introduction. --
History. --
Control of Activation Pathways. --
Control in the Membrane Attack Pathway. --
Control of the Anaphylactic Peptides. --
Summary. --
Regulation in the Activation Pathways: --
Regulation of C1. --
Regulators Encoded in the RCA Gene Cluster. --
Other Regulators of the Activation Pathways. --
Regulation in the Terminal Pathway: --
Introduction. --
Fluid-Phase Regulators of the Terminal Pathway. --
Membrane Regulators of the Terminal Pathway. --
Recovery from C Membrane Attack. --
Concluding Remarks. --
Deficiencies of Complement Regulators: --
Introduction, Deficiency of C1 Inhibitor (C1inh). --
Deficiencies of Fluid-Phase C3 Convertase Regulators. --
Deficiencies of Fluid-Phase Membrane Attack Pathway Regulators. --
Deficiencies of Membrane Regulators of C. --
Concluding Remarks. --
Complement Regulation in the Reproductive System: --
Introduction. --
Role of C Inhibitors in the Protection of Sperm. --
Role of C Regulators in Protection of the Fetus. --
The Role of MCP in Fertilization. --
Concluding Remarks. --
Complement Regulators and Micro-Organisms: --
Introduction. --
Complement Regulators as Receptors for Microorgansims. --
Hijacking of Complement Regulators by Microorganisms. --
Molecular Mimicry. --
C5a-Peptidase/C5a-ASE. --
Conclusions. --
Complement Regulatory Proteins in Other Species: --
Introduction. --
Regulators of the Activation pathways. --
Regulators of the Terminal Pathway. --
Manipulation of Membrane C Regulators In Vivo. --
Complement Regulators in Therapy: --
Introduction. --
Therapy with Soluble C Regulators. --
Antibodies Against C Components as Therapeutics. --
Complement Regulators in Xenotransplantation. --
Anti-CRP Antibodies and Therapy. --
Concluding Remarks. --
Bibliography. Complement system: a brief overview --
Regulation in the complement system --
Regulation in the activation pathways --
Regulation in the terminal pathway --
Deficiencies of complement regulators --
Complement regulation in the reproductive system --
Complement regulators and micro-organisms --
Complement regulatory proteins in other species --
Complement regulators in therapy.
Responsibility: B. Paul Morgan and Claire L. Harris.
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Abstract:

Discusses the 'nuts-and-bolts' of the complement regulators, describing their structures, functional roles and modes of action. This book describes the roles of the complement regulators in vivo,  Read more...

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    schema:description "The Complement System: A Brief Overview: -- Introduction. -- Activation of C. -- Physiological Roles of C. -- Involvement of C in Pathology. -- Why a Book on C Regulators? -- Regulation in the Complement System: -- Introduction. -- History. -- Control of Activation Pathways. -- Control in the Membrane Attack Pathway. -- Control of the Anaphylactic Peptides. -- Summary. -- Regulation in the Activation Pathways: -- Regulation of C1. -- Regulators Encoded in the RCA Gene Cluster. -- Other Regulators of the Activation Pathways. -- Regulation in the Terminal Pathway: -- Introduction. -- Fluid-Phase Regulators of the Terminal Pathway. -- Membrane Regulators of the Terminal Pathway. -- Recovery from C Membrane Attack. -- Concluding Remarks. -- Deficiencies of Complement Regulators: -- Introduction, Deficiency of C1 Inhibitor (C1inh). -- Deficiencies of Fluid-Phase C3 Convertase Regulators. -- Deficiencies of Fluid-Phase Membrane Attack Pathway Regulators. -- Deficiencies of Membrane Regulators of C. -- Concluding Remarks. -- Complement Regulation in the Reproductive System: -- Introduction. -- Role of C Inhibitors in the Protection of Sperm. -- Role of C Regulators in Protection of the Fetus. -- The Role of MCP in Fertilization. -- Concluding Remarks. -- Complement Regulators and Micro-Organisms: -- Introduction. -- Complement Regulators as Receptors for Microorgansims. -- Hijacking of Complement Regulators by Microorganisms. -- Molecular Mimicry. -- C5a-Peptidase/C5a-ASE. -- Conclusions. -- Complement Regulatory Proteins in Other Species: -- Introduction. -- Regulators of the Activation pathways. -- Regulators of the Terminal Pathway. -- Manipulation of Membrane C Regulators In Vivo. -- Complement Regulators in Therapy: -- Introduction. -- Therapy with Soluble C Regulators. -- Antibodies Against C Components as Therapeutics. -- Complement Regulators in Xenotransplantation. -- Anti-CRP Antibodies and Therapy. -- Concluding Remarks. -- Bibliography."@en ;
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