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Complex enzymes in microbial natural product biosynthesis. Part A, Overview articles and peptides

Author: D A Hopwood
Publisher: Amsterdam ; Boston ; London : Elsevier ; San Diego, Calif : Academic Press, 2009.
Series: Methods in enzymology, v. 458.
Edition/Format:   eBook : Document : English : 1st edView all editions and formats
Summary:
Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Complex enzymes in microbial natural product biosynthesis. Part A, Overview articles and peptides.
Amsterdam ; Boston : Elsevier/Academic Press, 2009
(OCoOC)319600648
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: D A Hopwood
ISBN: 9780080923352 0080923356 9780123745880 0123745888
OCLC Number: 318585918
Description: 1 online resource (xlix, 636 pages) : illustrations.
Contents: Part 1: Overview articlesIntroduction - chemical classes of complex natural products and overview of their biosynthesisDiscovery of novel natural productsTrans-modification of intermediates on the assembly line in PKS, FAS and NRPS biosynthesisPost-assembly line modifications, including glycosylationCloning and analysis of natural product pathwaysIn silico prediction of pathways from DNA sequenceMass spectrometric analysis of PKS and NRPS biosynthetic intermediatesSynthetic probes for PKS and NRPS biochemistryDirected evolution of natural productsExpression in a heterologous hostPathway-specific and global regulation of antibiotic biosynthesis: Regulation of antibiotic production by bacterial hormones:Part 2: PeptidesA. Non-ribosomally-synthesised peptidesOverview of NRPSs, and mechanistic and structural studiesSiderophoresCephamycins and clavulanic acidGlycopeptidesLipopeptidesPrecursor BiosynthesisB. Ribosomally synthesised peptidesLantibiotic biosynthesis and engineering of novel compoundsCyclic peptides from marine bacteria
Series Title: Methods in enzymology, v. 458.
Responsibility: edited by David A. Hopwood.

Abstract:

Intends to showcase the important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the  Read more...

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