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Complex Mixtures : Methods for In Vivo Toxicity Testing.

Author: National Research Council Staff
Publisher: Washington : National Academies Press, 1900.
Edition/Format:   eBook : Document : EnglishView all editions and formats
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Staff, National Research Council.
Complex Mixtures : Methods for In Vivo Toxicity Testing.
Washington : National Academies Press, ©1900
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: National Research Council Staff
ISBN: 9780309555135 0309555132
OCLC Number: 923267638
Notes: ""Maintenance of Sample Integrity""
Description: 1 online resource (240 pages)
Contents: ""Complex Mixtures""; ""Copyright""; ""Preface""; ""Contents""; ""Executive Summary""; ""1 Introduction ""; ""DEFINITIONS""; ""STRUCTURE OF THE REPORT""; ""2 Concepts for Analyzing Human Exposure to Complex Chemical Mixtures ""; ""GENERAL CONCEPTS""; ""Dose and Dose Surrogates""; ""Indicators of Exposure to Complex Mixtures as Dose Surrogates""; ""Effects of Matrix and Physical State on Dose""; ""Factors Influencing Relationships Between Exposure and Dose""; ""EFFECT OF POPULATION AND EXPOSURE COMPLEXITY ON QUALITATIVE ASSESSMENT""; ""Complexity of Exposure""; ""Complexity of Populations"" ""Interactive Effects of Multiple Exposures""""Complexity of Health Effects""; ""CONSIDERATIONS IN QUANTITATION OF HUMAN EXPOSURES IN EPIDEMIOLOGIC STUDIES""; ""Ambient Exposure""; ""Concentrations in Air, Water, and Food""; ""Biologic Sampling Data""; ""Exposure Histories""; ""Some Statistical Issues in Quantitation of Exposure""; ""PREDICTIVE VALUE OF LABORATORY STUDIES FOR HUMAN EFFECTS OF ENVIRONMENTAL EXPOSURES""; ""Exposure as a Variable""; ""Complexity of the Agent as a Variable""; ""Limitations of Animal Models""; ""Tosicokinetics"" ""SUMMARIES OF EXAMPLES OF HUMAN EXPOSURES TO COMPLEX CHEMICAL MIXTURES""""Sulfur Dioxide and Suspended Particulate Matter""; ""Lead and Nutritional Factors�Effects on Blood Pressure""; ""Radon Daughters and Cigarette Smoke""; ""Asbestos Exposure and Cigarette-Smoking""; ""Cigarette-Smoking and Alcoholic-Beverage Consumption as Risk Factors in the Etiology of Oral Cancer""; ""Trihalomethanes and Other Byproducts of Chlorination in Drinking Water""; ""Coke-Oven Emissions""; ""Coal-Mine Dust""; ""REFERENCES""; ""3 Testing Strategies and Methods ""; ""PROBLEM AND QUESTION DEFINITION"" ""Questions Related to Effects""""Questions Related to Causative Agents""; ""Questions Related to Predictability""; ""STRATEGIES""; ""Strategies Related to Effects""; ""Tier Testing""; ""Screening Studies""; ""Matrix Testing""; ""Battery Approach""; ""Comparative-Potency Approach""; ""Strategies Related to Causative Agents""; ""Bioassay-Directed Fractionation""; ""Pairing""; ""Chemical Search""; ""Effect Search""; ""Bioassay Identification""; ""Strategies Related to Predictability and Models""; ""Testing Mixture Components""; ""Mechanistic Studies and Models for Interactions"" ""Empirical Models""""Aquatic Test Systems""; ""INTEGRATION OF STRATEGIES""; ""COMPLEXITY OF MIXTURE""; ""Knowledge of Constituents and Effects""; ""Problems or Questions in Relation to Strategies""; ""Formulation of Overall Strategy""; ""REFERENCES""; ""4 Sampling and Chemical Characterization ""; ""CLASSIFICATION""; ""SAMPLING""; ""Collection Strategy""; ""Exposure""; ""Meteorology""; ""Temporal Factors""; ""Spatial Considerations""; ""Collection Procedure""; ""Gases and Aerosols""; ""Aqueous Materials""; ""Nonaqueous Materials""; ""Solids and Sediments""

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