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Conformation in biology and drug design

Author: Victor J Hruby
Publisher: Orlando : Academic Press, 1985.
Series: Peptides (Academic Press), v. 7.
Edition/Format:   eBook : Document : EnglishView all editions and formats
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Conformation in Biology and Drug Design.
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Conformation in biology and drug design
(DLC) 78031958
(OCoLC)17918575
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Victor J Hruby
ISBN: 9781483218007 1483218007
OCLC Number: 893872985
Description: 1 online resource (xix, 495 pages) : illustrations.
Contents: Front Cover; Conformation in Biology and DrugDesign; Copyright Page; Table of Contents; Contributors; Preface; Nomenclature and Abbreviations; Chapter 1. A Perspective on the Application of Physical Methods to Peptide Conformational-Biological Activity Studies; I. Introduction; II. Some Biological Considerations; III. Historical Development of Peptide Conformational Studies in Solution; IV. Theoretical Methods for Examining Peptide Conformations; V. Application of Conformational and Dynamic Studies of Peptides to Their Biological Activities; Acknowledgment; References. Chapter 2. Circular Dichroism of PeptidesI. Introduction; II. General Aspects of Peptide CD; III. Specific Systems; Acknowledgments; References; Chapter 3. Application of Fluorescence Techniques in Studies of Peptide Conformations and Interactions; I. Introductory Remarks; II. Fluorophores in Peptides; III. Fluorescence Quantum Yield and Lifetime Measurements; IV. Fluorescence Polarization Studies; V. Measurement of Intramolecular Distances by Singlet-Singlet Resonance Energy Transfer Experiments; VI. Fluorescence Studies of Peptide Interactions with Macromolecular Systems; VII. Concluding Remarks. AcknowledgmentReferences; Chapter 4. Theoretical Methods in the Analysis of Peptide Conformation; I. Introduction; II. Definitions and Conventions; III. Methodology; IV. Results; References; Chapter 5. Theoretical Simulation of Conformation, Energetics, and Dynamics of Peptides; I. Introduction; II. Techniques and Methodology; III. Applications; IV. Summary and Future Directions; Acknowledgments; References; Chapter 6. Paramagnetic Metal Ions as Nuclear Magnetic Resonance Probes of Peptide Conformation in Solution; I. Introduction; II. Paramagnetic Metal Ion-Induced Shifts and Relaxation Enhancements. III. ConclusionsReferences; Chapter 7. Nuclear Magnetic Resonance Studies ofPeptide-Macromolecule Interactions; I. Introduction; II. Nuclear Magnetic Resonance Techniques; III. Peptide-Protein Interaction; IV. Peptide-Lipid Interaction; V. Peptide-Nucleic Acid Interactions; VI. Conclusions and Prospects; References; Chapter 8. Solid-State Nuclear Magnetic Resonance of Peptides; I. Introduction; II. Methods; III. Applications; IV. Prospects; Acknowledgments; References; Chapter 9. Modern Nuclear Magnetic Resonance Spectroscopy of Peptides; I. Introduction; II. Conformational Homogeneity. III. General Strategy for Nuclear Magnetic Resonance Investigation of PeptidesIV. Assignment of Proton Nuclear Magnetic Resonance Signals; V. Heteronuclear Techniques; VI. Sequence Analysis; VII. Quantitative Evaluation of Nuclear Magnetic Resonance Spectra; VIII. Conclusions; Acknowledgments; References; Index.
Series Title: Peptides (Academic Press), v. 7.
Responsibility: edited by Victor J. Hruby.

Abstract:

Conformation in Biology and Drug Design.

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