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Conn's handbook of models for human aging

Author: Jeffrey L Ram; P Michael Conn
Publisher: London, United Kingdom : Elsevier Ltd. : Academic Press, [2018]
Edition/Format:   eBook : Document : English : Second editionView all editions and formats
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Jeffrey L Ram; P Michael Conn
ISBN: 9780128113547 0128113545
OCLC Number: 1031373801
Notes: Includes index.
Description: 1 online resource
Contents: Intro; Title page; Table of Contents; Copyright; List of Contributors; Preface; Preface; Section I. Aging in Humans; Chapter 1. Werner Syndrome as a Model of Human Aging; Introduction and Historical Overview; Werner Syndrome as a Clinical Disease; Cancer in Werner Syndrome; Clinical Progression of Werner Syndrome; Diagnostic Criteria and Differential Diagnosis; The WRN Gene and Disease-Associated Mutations; Atypical WS/Other Heritable Progeroid Syndromes Distinct From WS; WRN Protein Function in Human Cells; The Relationship of Werner Syndrome to Normal Aging. Experimental Models of Werner SyndromePotential Therapeutic Targets and Strategies; Concluding Remarks; Print Resources; Web Resources; Chapter 2. Premature Aging Syndrome; Introduction; Hutchinson-Gilford Progeria and Werner Syndrome; Causative Genes and Molecular Mechanisms; Management and Therapeutic Approaches; Cell Culture Models; Mouse Models; Conclusions; Chapter 3. Models, Definitions, and Criteria for Frailty; Introduction; Models and Mechanisms; Definition; Criteria; Conclusion; Recommended Resources. Chapter 4. Immunological Methods and the Concept of Inflammaging in the Study of Human AgingIntroduction; Phenotypic Analyses; Functional Analyses; Inflammaging; A Dysregulatory Approach Integrating the Immune System and Other Systems; Conclusion; Chapter 5. Vulnerability and Experiential Health in Old Age-A Qualitative Perspective; Introduction; Aging in the World of Meanings; Qualitative Methods as the Study of Meanings; The Meaning and Experience of Vulnerability in Old Age; Experiential Health in Old Age; Researching Subjectivity-Comments on Research Ethics. Chapter 6. Body Composition in Older AdultsIntroduction; Overview and Understanding of Body Composition and Compartments; Aging-Related Changes in Body Composition; Measurement of Aging-Related Changes in Body Composition in Clinical Practice; Chapter 7. Using Computational Models to Study Aging; Introduction; The Interconnected Nature of Aging; Why Computational Models Are Needed to Study Health Span?; What Is a Computational Model?; The Steps Involved in Building a Computer Model; Mathematical Frameworks; Modeling Software and Modeling Standards. Computational Modeling of Intracellular ProcessesModeling Nutrient Focused Cellular Pathways; Whole Body Models and Health Span; Opportunities and Future Challenges; Conclusions; Chapter 8. A Framework for Uncovering the Roles of Calories and Macronutrients in Health and Aging; Introduction; Calorie Restriction; Invertebrate Models; Mammalian Models; Calorie Restriction: Is It Plausible for Humans?; Studies of Protein and Amino Acid Restriction; Limitations of Single-Nutrient Manipulation Approaches; The Geometric Framework; Geometric Designs for Aging Research; From Insects to Mice.
Responsibility: editors, Jeffrey L. Ram, P. Michael Conn.

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