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Corpus callosum in maltreated children with posttraumatic stress disorder: a diffusion tensor imaging study.
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Corpus callosum in maltreated children with posttraumatic stress disorder: a diffusion tensor imaging study.

Author: AP Jackowski Affiliation: Child Study Center, Yale University School of Medicine, New Haven, CT, United States.H Douglas-PalumberiM JackowskiL WinRT SchultzAll authors
Edition/Format: Article Article : English
Publication:Psychiatry research, 2008 Apr 15; 162(3): 256-61
Database:From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Summary:
Contrary to expectations derived from preclinical studies of the effects of stress, and imaging studies of adults with posttraumatic stress disorder (PTSD), there is no evidence of hippocampus atrophy in children with PTSD. Multiple pediatric studies have reported reductions in the corpus callosum--the primary white matter tract in the brain. Consequently, in the present study, diffusion tensor imaging was used to  Read more...
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Details

Document Type: Article
All Authors / Contributors: AP Jackowski Affiliation: Child Study Center, Yale University School of Medicine, New Haven, CT, United States.; H Douglas-Palumberi; M Jackowski; L Win; RT Schultz; LW Staib; JH Krystal; J Kaufman
ISSN:0165-1781
Language Note: English
Unique Identifier: 264093431
Awards:

Abstract:

Contrary to expectations derived from preclinical studies of the effects of stress, and imaging studies of adults with posttraumatic stress disorder (PTSD), there is no evidence of hippocampus atrophy in children with PTSD. Multiple pediatric studies have reported reductions in the corpus callosum--the primary white matter tract in the brain. Consequently, in the present study, diffusion tensor imaging was used to assess white matter integrity in the corpus callosum in 17 maltreated children with PTSD and 15 demographically matched normal controls. Children with PTSD had reduced fractional anisotropy in the medial and posterior corpus, a region which contains interhemispheric projections from brain structures involved in circuits that mediate the processing of emotional stimuli and various memory functions--core disturbances associated with a history of trauma. Further exploration of the effects of stress on the corpus callosum and white matter development appears a promising strategy to better understand the pathophysiology of PTSD in children.

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