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Corpus callosum in maltreated children with posttraumatic stress disorder: a diffusion tensor imaging study.
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Corpus callosum in maltreated children with posttraumatic stress disorder: a diffusion tensor imaging study.

著者: AP Jackowski 附属: Child Study Center, Yale University School of Medicine, New Haven, CT, United States.H Douglas-PalumberiM JackowskiL WinRT Schultz所有著者
版本/格式: 文章 文章 : 英语
刊登在:Psychiatry research, 2008 Apr 15; 162(3): 256-61
数据库:取自MEDLINE®/PubMed®,这是美国医学图书馆的一个数据库。
提要:
Contrary to expectations derived from preclinical studies of the effects of stress, and imaging studies of adults with posttraumatic stress disorder (PTSD), there is no evidence of hippocampus atrophy in children with PTSD. Multiple pediatric studies have reported reductions in the corpus callosum--the primary white matter tract in the brain. Consequently, in the present study, diffusion tensor imaging was used to  再读一些...
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文件类型: 文章
所有的著者/提供者: AP Jackowski 附属: Child Study Center, Yale University School of Medicine, New Haven, CT, United States.; H Douglas-Palumberi; M Jackowski; L Win; RT Schultz; LW Staib; JH Krystal; J Kaufman
ISSN:0165-1781
语言注释: English
专有的标识符 264093431
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摘要:

Contrary to expectations derived from preclinical studies of the effects of stress, and imaging studies of adults with posttraumatic stress disorder (PTSD), there is no evidence of hippocampus atrophy in children with PTSD. Multiple pediatric studies have reported reductions in the corpus callosum--the primary white matter tract in the brain. Consequently, in the present study, diffusion tensor imaging was used to assess white matter integrity in the corpus callosum in 17 maltreated children with PTSD and 15 demographically matched normal controls. Children with PTSD had reduced fractional anisotropy in the medial and posterior corpus, a region which contains interhemispheric projections from brain structures involved in circuits that mediate the processing of emotional stimuli and various memory functions--core disturbances associated with a history of trauma. Further exploration of the effects of stress on the corpus callosum and white matter development appears a promising strategy to better understand the pathophysiology of PTSD in children.

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