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Corpus callosum in maltreated children with posttraumatic stress disorder: a diffusion tensor imaging study.
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Corpus callosum in maltreated children with posttraumatic stress disorder: a diffusion tensor imaging study.

作者: AP Jackowski 有關機構: Child Study Center, Yale University School of Medicine, New Haven, CT, United States.H Douglas-PalumberiM JackowskiL WinRT Schultz所有作者
版本/格式: 文章 文章 : 英語
刊登於:Psychiatry research, 2008 Apr 15; 162(3): 256-61
資料庫:取自MEDLINE®/PubMed®,這是美國醫學圖書館的一個資料庫。
提要:
Contrary to expectations derived from preclinical studies of the effects of stress, and imaging studies of adults with posttraumatic stress disorder (PTSD), there is no evidence of hippocampus atrophy in children with PTSD. Multiple pediatric studies have reported reductions in the corpus callosum--the primary white matter tract in the brain. Consequently, in the present study, diffusion tensor imaging was used to  再讀一些...
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文件類型: 文章
所有的作者/貢獻者: AP Jackowski 有關機構: Child Study Center, Yale University School of Medicine, New Haven, CT, United States.; H Douglas-Palumberi; M Jackowski; L Win; RT Schultz; LW Staib; JH Krystal; J Kaufman
ISSN:0165-1781
語言註釋: English
專有的識別號: 264093431
獎賞:

摘要:

Contrary to expectations derived from preclinical studies of the effects of stress, and imaging studies of adults with posttraumatic stress disorder (PTSD), there is no evidence of hippocampus atrophy in children with PTSD. Multiple pediatric studies have reported reductions in the corpus callosum--the primary white matter tract in the brain. Consequently, in the present study, diffusion tensor imaging was used to assess white matter integrity in the corpus callosum in 17 maltreated children with PTSD and 15 demographically matched normal controls. Children with PTSD had reduced fractional anisotropy in the medial and posterior corpus, a region which contains interhemispheric projections from brain structures involved in circuits that mediate the processing of emotional stimuli and various memory functions--core disturbances associated with a history of trauma. Further exploration of the effects of stress on the corpus callosum and white matter development appears a promising strategy to better understand the pathophysiology of PTSD in children.

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