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Current topics in human genetics : studies in complex diseases

Author: Hong-wen Deng; Hui Shen
Publisher: Hackensack, NJ : World Scientific, ©2007.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

Application of genomic, proteomic, and bioinformatics technologies to study of human genetics has made it possible for human genetic diseases to be studied on an unprecedented scale. This work  Read more...

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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Hong-wen Deng; Hui Shen
ISBN: 9789812704726 9812704728
OCLC Number: 124165005
Description: xii, 950 pages : illustrations (some color) ; 24 cm
Contents: Regression-based linkage analysis methods --
Admixture mapping: methods and applications --
Survival analysis methods in genetic epidemiology --
Genetic association studies: concepts and applications --
Tag SNP selection and its applications in association studies --
Haplotype inference and association analysis in unrelated samples --
Survey on haplotyping algorithms for tightly linked markers --
DNA pooling: methods and applications in association studies --
Linkage disequilibrium and test for interaction between two loci --
Association tests for complex disease genes while controlling population stratification --
Statistical methods for multiple QTL mapping in experimental crosses --
Animal models in the study of genetics of complex human diseases --
Acquisition of accurate gene expression information from microarray measurements --
Application of DNA microarray technology in genetics --
Expression quantitative trait locus (eQTL) mapping --
Bridging genotype and phenotype: causal pathways from DNA to complex traits --
Functional proteomics and its application in biomedical sciences --
Introduction to biomedical informatics --
Protein-protein interactions: concepts, databases, software tools, and biomedical implications --
Genomic cloning in the postgenome era --
RNA metabolism and human diseases --
Recent progress in the genetics of osteoporosis --
Critical molecules in bone development and genetic bone diseases --
Genetic factors for human type 1 diabetes --
Genetic susceptibility to human obesity --
Genes in estrogen metabolism pathway and breast cancer --
Hereditary breast and ovarian cancers --
Activation of Wnt signaling in tumor development --
Genetics of autoimmune diseases: MHC and beyond --
Genetics of substance dependence --
Insulin resistance and metabolic syndrome --
Genetics of intracellular traffic jams: multi-organellar defects.
Responsibility: co-editors-in-chief, Hong-Wen Deng, Hui Shen ; associate editors, Yong-Jun Liu, Hai Hu.
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