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Cyathuscavins A, B, and C, new free radical scavengers with DNA protection activity from the Basidiomycete <b>Cyathus stercoreus</b>
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Cyathuscavins A, B, and C, new free radical scavengers with DNA protection activity from the Basidiomycete Cyathus stercoreus

Author: Hahk-Soo Kang Affiliation: Korea Research Institute of Bioscience and Biotechnology, Functional Metabolite Research Center, 52 Eoeun-dong, Yuseong, Daejeon 305-806, Republic of KoreaKyoung-Rok Kim Affiliation: Department of Biological Science, Division of Bioscience and Bioinformatics, Myongji University, Yongin 449-728, Republic of KoreaEun-Mi Jun Affiliation: Korea Research Institute of Bioscience and Biotechnology, Functional Metabolite Research Center, 52 Eoeun-dong, Yuseong, Daejeon 305-806, Republic of KoreaSoon-Hye Park Affiliation: Korea Research Institute of Bioscience and Biotechnology, Functional Metabolite Research Center, 52 Eoeun-dong, Yuseong, Daejeon 305-806, Republic of KoreaTae-Soo Lee Affiliation: Department of Biology, University of Incheon, Incheon 402-709, Republic of KoreaAll authors
Edition/Format: Article Article : English
Publication:Bioorganic & Medicinal Chemistry Letters, v18 n14 (20080715): 4047-4050
Other Databases: WorldCatWorldCat
Summary:
Cyathuscavins A-C (1-3) showing free radical scavenging activity and DNA protection activity were reported.
Three new polyketides, cyathuscavins A (1), B (2), and C (3) were isolated from the mycelium culture of Cyathus stercoreus. The structures of the compounds were elucidated on the basis of NMR and mass spectroscopic data. Antioxidant activities of the compounds were evaluated by the scavenging ability against ABTS+, DPPH, and superoxide anion radicals. Cyathuscavins A-C showed significant antioxidant activity comparable to those of reference antioxidants, BHA and Trolox. Cyathuscavins A-C protected supercoiled plasmid DNA from Fe2+/H2O2-induced breakage.  Read more...
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Document Type: Article
All Authors / Contributors: Hahk-Soo Kang Affiliation: Korea Research Institute of Bioscience and Biotechnology, Functional Metabolite Research Center, 52 Eoeun-dong, Yuseong, Daejeon 305-806, Republic of Korea; Kyoung-Rok Kim Affiliation: Department of Biological Science, Division of Bioscience and Bioinformatics, Myongji University, Yongin 449-728, Republic of Korea; Eun-Mi Jun Affiliation: Korea Research Institute of Bioscience and Biotechnology, Functional Metabolite Research Center, 52 Eoeun-dong, Yuseong, Daejeon 305-806, Republic of Korea; Soon-Hye Park Affiliation: Korea Research Institute of Bioscience and Biotechnology, Functional Metabolite Research Center, 52 Eoeun-dong, Yuseong, Daejeon 305-806, Republic of Korea; Tae-Soo Lee Affiliation: Department of Biology, University of Incheon, Incheon 402-709, Republic of Korea; Joo-Won Suh Affiliation: Department of Biological Science, Division of Bioscience and Bioinformatics, Myongji University, Yongin 449-728, Republic of Korea; Jong-Pyung Kim Affiliation: Korea Research Institute of Bioscience and Biotechnology, Functional Metabolite Research Center, 52 Eoeun-dong, Yuseong, Daejeon 305-806, Republic of Korea
ISSN:0960-894X
Language Note: English
Unique Identifier: 5902149510
Notes: Corresponding author. Tel.: +82 42 860 4333; fax: +82 42 860 4595.
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Abstract:

Cyathuscavins A-C (1-3) showing free radical scavenging activity and DNA protection activity were reported.
Three new polyketides, cyathuscavins A (1), B (2), and C (3) were isolated from the mycelium culture of Cyathus stercoreus. The structures of the compounds were elucidated on the basis of NMR and mass spectroscopic data. Antioxidant activities of the compounds were evaluated by the scavenging ability against ABTS+, DPPH, and superoxide anion radicals. Cyathuscavins A-C showed significant antioxidant activity comparable to those of reference antioxidants, BHA and Trolox. Cyathuscavins A-C protected supercoiled plasmid DNA from Fe2+/H2O2-induced breakage.

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