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Cyclic-nucleotide phosphodiesterases in the central nervous system : from biology to drug discovery

Author: Nicholas J Brandon; Anthony R West
Publisher: Hoboken, New Jersey : John Wiley & Sons, Inc., [2014]
Series: Wiley series in drug discovery and development.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:

This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe  Read more...

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Genre/Form: Electronic books
Additional Physical Format: Print version:
Cyclic-nucleotide phosphodiesterases in the central nervous system.
Hoboken, New Jersey : John Wiley & Sons, Inc., [2014]
(DLC) 2013042742
(OCoLC)861755359
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Nicholas J Brandon; Anthony R West
ISBN: 9781118836323 1118836324 9781118836309 1118836308 9781118836538 1118836537 9781118836507 1118836502 047056668X 9780470566688
OCLC Number: 861789137
Description: 1 online resource (xi, 386 pages) : illustrations (some color).
Contents: Phosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter --
Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly --
Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin --
Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup --
Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella --
Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang --
Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell --
Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa --
Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P.P. Bollen, Kris Rutten, Olga A.H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts --
Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon --
Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West --
The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick --
Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin.
Series Title: Wiley series in drug discovery and development.
Responsibility: edited by Nicholas J. Brandon, Anthony R. West.
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