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The D-limited Mouse : a globally altered antibody repertoire shaped by the principle of CDR3 hydropathicity

Autore: Gregory C Ippolito
Editore: 2002.
Tesi: Ph. D. University of Alabama at Birmingham, School of Joint Health Sciences 2002
Edizione/Formato:   Tesi/dissertazione : Thesis/dissertation : Manuscript   Materiale d’archivio : English
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Tipo materiale: Thesis/dissertation, Manuscript
Tipo documento Libro, Materiale d’archivio
Tutti gli autori / Collaboratori: Gregory C Ippolito
Numero OCLC: 53196546
Descrizione: xi, 95 leaves : illustrations ; 29 cm
Responsabilità: by Gregory C. Ippolito.
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Evolutionary conservation of IgH D gene segments

da DFL16.1 (Utenti WorldCat. Pubblicazioni 2009-10-08) Molto buono Link permanente

Gene targeted mice were made wherein the IgH locus of germline D gene segments (~ 80 kb) was deleted by Cre-loxP engineering in ES cells.  The locus was replaced by a single D gene element -- either germline DFL16.1 (encoding Tyr, Ser, and Gly) or an inverted DFL16.1 (encoding the charged residues...
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