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The D-limited Mouse : a globally altered antibody repertoire shaped by the principle of CDR3 hydropathicity

Auteur: Gregory C Ippolito
Uitgever: 2002.
Proefschrift: Ph. D. University of Alabama at Birmingham, School of Joint Health Sciences 2002
Editie/Formaat:   Scriptie/Proefschrift : Scriptie/Dissertatie : Manuscript   Archiefmateriaal : Engels
Database:WorldCat
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Genre: Scriptie/Dissertatie, Manuscript
Soort document: Boek, Archiefmateriaal
Alle auteurs / medewerkers: Gregory C Ippolito
OCLC-nummer: 53196546
Beschrijving: xi, 95 leaves : illustrations ; 29 cm
Verantwoordelijkheid: by Gregory C. Ippolito.
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Evolutionary conservation of IgH D gene segments

door DFL16.1 (Gepubliceerd door gebruiker WorldCat 2009-10-08) Heel goed Permalink

Gene targeted mice were made wherein the IgH locus of germline D gene segments (~ 80 kb) was deleted by Cre-loxP engineering in ES cells.  The locus was replaced by a single D gene element -- either germline DFL16.1 (encoding Tyr, Ser, and Gly) or an inverted DFL16.1 (encoding the charged residues...
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