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The D-limited Mouse : a globally altered antibody repertoire shaped by the principle of CDR3 hydropathicity

Autor: Gregory C Ippolito
Editora: 2002.
Dissertação: Ph. D. University of Alabama at Birmingham, School of Joint Health Sciences 2002
Edição/Formato   Tese/dissertação : Tese/dissertação : Manuscrito   Material de arquivo : Inglês
Base de Dados:WorldCat
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baseado em 1 classificação(ões) 1 com uma crítica

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Detalhes

Tipo de Material: Tese/dissertação, Manuscrito
Tipo de Documento Livro, Material de arquivo
Todos os Autores / Contribuintes: Gregory C Ippolito
Número OCLC: 53196546
Descrição: xi, 95 leaves : illustrations ; 29 cm
Responsabilidade: by Gregory C. Ippolito.
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Evolutionary conservation of IgH D gene segments

por DFL16.1 (Usuário WorldCat publicado 2009-10-08) Muito Bom Permalink

Gene targeted mice were made wherein the IgH locus of germline D gene segments (~ 80 kb) was deleted by Cre-loxP engineering in ES cells.  The locus was replaced by a single D gene element -- either germline DFL16.1 (encoding Tyr, Ser, and Gly) or an inverted DFL16.1 (encoding the charged residues...
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