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The D-limited Mouse : a globally altered antibody repertoire shaped by the principle of CDR3 hydropathicity

著者: Gregory C Ippolito
出版商: 2002.
论文: Ph. D. University of Alabama at Birmingham, School of Joint Health Sciences 2002
版本/格式:   硕士/博士论文 : 硕士论文/博士论文 : 手稿   档案资料 : 英语
数据库:WorldCat
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材料类型: 硕士论文/博士论文, 手稿
文件类型: 书, 档案资料
所有的著者/提供者: Gregory C Ippolito
OCLC号码: 53196546
描述: xi, 95 leaves : illustrations ; 29 cm
责任: by Gregory C. Ippolito.
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Evolutionary conservation of IgH D gene segments

评论者是 DFL16.1 (公布的WorldCat用户 2009-10-08) 很好 Permalink

Gene targeted mice were made wherein the IgH locus of germline D gene segments (~ 80 kb) was deleted by Cre-loxP engineering in ES cells.  The locus was replaced by a single D gene element -- either germline DFL16.1 (encoding Tyr, Ser, and Gly) or an inverted DFL16.1 (encoding the charged residues...
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