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The D-limited Mouse : a globally altered antibody repertoire shaped by the principle of CDR3 hydropathicity

作者: Gregory C Ippolito
出版商: 2002.
論文: Thesis (Ph. D.)--University of Alabama at Birmingham, School of Joint Health Sciences, 2002.
版本/格式:   碩士/博士論文 : 碩士論文/博士論文 : 手稿   文檔資料 : 英語
資料庫:WorldCat
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資料類型: 碩士論文/博士論文, 手稿
文件類型: 圖書, 文檔資料
所有的作者/貢獻者: Gregory C Ippolito
OCLC系統控制編碼: 53196546
描述: xi, 95 leaves : ill. ; 29 cm.
責任: by Gregory C. Ippolito.

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Evolutionary conservation of IgH D gene segments

評論者是 DFL16.1 (WorldCat讀者所發佈的 2009-10-08) 很好 Permalink

Gene targeted mice were made wherein the IgH locus of germline D gene segments (~ 80 kb) was deleted by Cre-loxP engineering in ES cells.  The locus was replaced by a single D gene element -- either germline DFL16.1 (encoding Tyr, Ser, and Gly) or an inverted DFL16.1 (encoding the charged residues...
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