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Design and analysis of vaccine studies

Author: M Elizabeth Halloran; Ira M Longini; Claudio J Struchiner
Publisher: New York : Springer, 2009.
Series: Statistics for biology and health.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Widespread immunization has many different kinds of effects in individuals and populations, including in the unvaccinated individuals. The challenge is in understanding and estimating all of these effects. This book presents a unified conceptual framework of the different effects of vaccination at the individual and at the population level. The book covers many different vaccine effects, including vaccine efficacy  Read more...
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Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: M Elizabeth Halloran; Ira M Longini; Claudio J Struchiner
ISBN: 0387403132 9780387403137 0387686363 9780387686363
OCLC Number: 631609875
Description: 1 online resource (xviii, 387 pages) : illustrations (some color).
Contents: Introduction and examples --
Overview of vaccine effects and study designs --
Immunology and early phase trials --
binomial and stochastic transmission models --
R0 and deterministic models --
Evaluating protective effects of vaccination --
Modes of action and time-varying VES --
Further Evaluation of Protective Effects --
Vaccine effects on post-infection outcomes --
House-hold based studies --
Analysis of households in communities --
Analysis of independent households --
Assessing Indirect, total and overall effects --
Randomization and baseline transmission --
Surrogates of protection.
Series Title: Statistics for biology and health.
Responsibility: M. Elizabeth Halloran, Ira M. Longini, Jr., Claudio J. Struchiner.
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Abstract:

As well as being a reference for the design, analysis, and interpretation of vaccine studies, the text covers all design and analysis stages, from vaccine development to post-licensure surveillance,  Read more...

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From the reviews: "...The first comprehensive book on the topic of vaccine trials, their design and analysis. Given the recent interest in developing vaccines, ...the book is timely, relevant and Read more...

 
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    schema:description "Introduction and examples -- Overview of vaccine effects and study designs -- Immunology and early phase trials -- binomial and stochastic transmission models -- R0 and deterministic models -- Evaluating protective effects of vaccination -- Modes of action and time-varying VES -- Further Evaluation of Protective Effects -- Vaccine effects on post-infection outcomes -- House-hold based studies -- Analysis of households in communities -- Analysis of independent households -- Assessing Indirect, total and overall effects -- Randomization and baseline transmission -- Surrogates of protection."@en ;
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