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Design and synthesis of organic molecules based on molecular recognition

Author: Georges van Binst
Publisher: Berlin ; New York : Springer-Verlag, ©1986.
Edition/Format:   Print book : Conference publication : EnglishView all editions and formats
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Genre/Form: Congresses
Conference papers and proceedings
Additional Physical Format: Online version:
Solvay Conference on Chemistry (18th : 1983 : Brussels, Belgium).
Design and synthesis of organic molecules based on molecular recognition.
Berlin ; New York : Springer-Verlag, ©1986
(OCoLC)569878462
Material Type: Conference publication
Document Type: Book
All Authors / Contributors: Georges van Binst
ISBN: 0387161236 9780387161235 3540161236 9783540161233
OCLC Number: 13010809
Description: xv, 315 pages : illustrations ; 25 cm
Contents: Design and Synthesis of Organic Molecules Based on Molecular Recognition.- Discussion.- Topic 1. Molecular Recognition in Biochemical Processes.- Reports.- Specific Reversible Interactions in Life Processes: Antenna Function of Membranes and Their Regioselective, Conformation Selective and Stereoselective Interactions with Regulatory Peptides.- Discussion.- Functional Significance of Flexibility in Proteins.- Discussion.- Communications.- Antibodies of Predetermined Specificity in Biology and Medicine.- Calcium Trigger Proteins.- Glucagon Conformation in Different Environments: Implications for Molecular Recognition.- Topic 2. Thermodynamics, Kinetics and Stereochemistry in Molecular Recognition.- Reports.- On the Economics of Binding Energies.- Discussion.- Dynamics of Ligand Binding to Proteins.- Discussion.- Binding Energy and the Stimulation of Hormone Receptors.- Discussion.- Theoretical Studies of Molecular Recognition and Catalysis by Enzymes.- Discussion.- Communications.- Why Water?.- Discussion.- Experimental Studies of Protein-Dynamics Through Ligand Binding.- Topic 3. Synthetic Models of "Hosts".- Reports.- Designed Host-Guest Relationships.- Discussion.- Molecular Recognition: Design of Abiotic Receptor Molecules.- Discussion.- Biomimetic Control of Chemical Selectivity.- Biopolymers in Reverse Micelles as Guest-Host Molecular Systems.- Discussion.- Communications.- Intimate Ion Pair Intermediates in the Solvolysis of Thio Addition Products of NAD (P)+ Analogs and Their Relevance to the Chemistry of 3-Phosphoglyceraldehyde Dehydrogenase.- Stereoselective Guest-Host Relationships.- Discussion.- On the Dynamics of Embedding in Imprinted Polymers.- Discussion.- Photo Reversible Affinity Labeling.- Discussion.- Topic 4. Design of New "Guests".- Reports.- Molecular Discrimination in Crystal Growth in the Presence of "Tailor-Made" Inhibitors.- Discussion.- Binding and Information Transfer in Conformationally Restricted Peptides.- Communications.- Chiral Recognition in Partitioning Systems.- Discussion.- Designing Activity and Receptor Selectivity in Cyclic Peptide Hormone Analogs.- Concluding Remarks.- Concluding Remarks by a Physicist.- Some Aspects on Chemical versus Biochemical Recognition and Catalysis.- List of Authors.
Responsibility: edited by Georges van Binst ; chairmen of the conference, Ephraim Katchalski-Katzir and Vladimir Prelog.

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