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Design of enzyme inhibitors as drugs

Author: Merton Sandler; H J Smith
Publisher: Oxford [England] ; New York : Oxford University Press, 1989.
Series: Oxford science publications.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

A collection of essays examining the major target enzymes and their inhibitors. The underlying physical and chemical processes of enzyme inhibition, the principles of inhibitor design using  Read more...

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Additional Physical Format: Online version:
Design of enzyme inhibitors as drugs.
Oxford [England] ; New York : Oxford University Press, 1989
(OCoLC)597425258
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Merton Sandler; H J Smith
ISBN: 0192615378 9780192615374
OCLC Number: 17413222
Description: xviii, 810 pages, [4] pages of plates : illustrations (some color) ; 24 cm.
Contents: Introduction to the use of enzyme inhibitors as drugs; general approaches to the design of inhibitors; inhibitors of the Renin-Angiotens in system enzymes; lactamase inhibitors; enkephalinase inhibitors as drugs; monoamine oxidase inhibitors; polyamine oxidase inhibitors; new developments in enzyme activated irreversible inhibitors of pyridoxal phosphate-dependent enzymes of therapeutic interest; cholinesterase and esterase inhibitors and reactivators of organophosphorus-inhibited esterases; inhibitors of enzymes of the arachidonic acid metabolic pathways; selective inhibitors of dihydrofolate reductases; the antibacterial sulphonamides; inhibitors of enzymes of the de novo pyrimidine pathway; inhibitors of purine biosynthesis; inhibitors of Na+, K+ ATpase; inhibitors of steriod biosynthesis; inhibitions of enzymes involved in bacterial cell wall synthesis; inhibition of proteinases; development of selective inhibitors of calmodulin-dependent phosphodiesterase and adenylate cyclase; inhibitors of carbonic anhydrase; inhibition of intracellular methyl transfer and aminopropyl transfer reactions by analogues of substrates, products, and transition states; inhibitors of some other target enzymes as potential clinical agents. Index.
Series Title: Oxford science publications.
Responsibility: edited by Merton Sandler and H. John Smith.
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