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  E-mail Message: I thought you might be interested in this item at http://www.worldcat.org/oclc/116045079 Title: Detection of antibodies to myotoxin a and prairie rattlesnake (Crotalus viridis viridis) venom in three antisera using enzyme-linked immunosorbent assay and immunodiffusion. Publisher: ISBN/ISSN: 0041-0101 OCLC:116045079

  
  

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Detection of antibodies to myotoxin a and prairie rattlesnake (Crotalus viridis viridis) venom in three antisera using enzyme-linked immunosorbent assay and immunodiffusion.

Author:	CL Ownby; GV Odell; RD Theakston
Edition/Format:	Article : English
Publication:	Toxicon : official journal of the International Society on Toxinology, 1983; 21(6): 849-55
Database:	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Summary:	Immunodiffusion and enzyme-linked immunosorbent assay (ELISA) were used to compare three antisera for their content of antibodies against myotoxin a and C. v. viridis venom. No antibodies were detected in Wyeth's polyvalent (Crotalidae) antivenin against myotoxin a using immunodiffusion, whereas ELISA indicated a low titer of such antibodies. However, antimyotoxin a serum and anti-C. v. viridis venom both had higher titers than antivenin when tested against myotoxin a and crude venom in the ELISA. These results correlate well with previous data which indicated that antiserum to myotoxin a was more effective than antivenin in neutralizing the myotoxicity of C. v. viridis venom. The high content of antibodies to myotoxin a in anti-C. v. viridis venom supports the hypothesis that this monovalent antiserum might be effective in neutralizing rattlesnake (C. v. viridis) venom-induced myonecrosis.  Read more...
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