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Developing therapeutics for Alzheimer's disease : progress and challenges

Author: Michael S Wolfe
Publisher: Amsterdam ; Boston : Elsevier/AP, Academic Press is an imprint of Elsevier, [2016] ©2016
Edition/Format:   Print book : EnglishView all editions and formats
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Document Type: Book
All Authors / Contributors: Michael S Wolfe
ISBN: 9780128021736 012802173X
OCLC Number: 938382920
Description: xx, 656 pages : illustrations ; 25 cm
Contents: 1. The Complex Pathways to Mechanism-Based Therapeutics in Alzheimer's Disease2. The Genetic Basis of Alzheimer's Disease3. B-Secretase Inhibition4. Y-Secretase Inhibitors: from Chemical Probes to Drug Development5. Therapeutic Targeting of AB426. Modulators of Amyloid B-Protein (AB) Self-Assembly7. Anti-Amyloid-B Immunotherapy for Alzheimer's Disease8. Targeting AB Receptors to Modify Alzheimer's Disease Progression9. Blood-Brain Barrier Transport of Alzheimer's Amyloid B-Peptide10. Alzheimer's Disease Therapeutics Targeting Apolipoprotein E11. Microtubule Stabilization12. Tau Phosphorylation as a Therapeutic Target in Alzheimer's Disease13. Stimulation of Tau Degradation 14. Passive Immunotherapy for Tau Pathology15. Inhibition of Tau Aggregation as a Basis for Treatment and Prevention of Alzheimer's Disease 16. Neuroprotective Strategies for Alzheimer's Disease Prevention and Therapy17. Symptomatic Cognitive Enhancing Agents18. Tackling Alzheimer's Disease by Targeting Oxidative Stress and Mitochondria19. Preclinical and Clinical Issues in Alzheimer Drug Development 20. Molecular Imaging in Alzheimer Clinical Trials21. Fluid Biomarkers and Diagnostics 22. Non-Pharmacologic Activity Interventions to Prevent Alzheimer's Disease23. Prospects and Challenges for Alzheimer Therapeutics
Other Titles: Therapeutics for Alzheimer's disease
Responsibility: edited by Michael S. Wolfe, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.

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