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Developments in T cell based cancer immunotherapies

Author: Paolo A Ascierto; David F Stroncek; Ena Wang
Publisher: Cham : Humana Press, 2015.
Series: Cancer drug discovery and development.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell function. Other topics covered include  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Developments in T Cell Based Cancer Immunotherapies.
Cham : Springer International Publishing, ©2015
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Paolo A Ascierto; David F Stroncek; Ena Wang
ISBN: 9783319211671 3319211676
OCLC Number: 930703384
Notes: Includes index.
Description: 1 online resource.
Contents: 1 New insight of peptide vaccination in cancer immunotherapy --
2 The determinants of T cell function for effective anticancer vaccine --
3 T cell fate in the tumor microenvironment --
4 T cell receptor avidity and affinity and tumor specific TCR engineer --
5 Host genetic variation and somatic alteration associated with favorable or compromised T cell function --
6 Production of Clinical T Cell Therapies --
7 Clinical success of adoptive cell transfer therapy using tumor infiltrating lymphocytes.-8 Harnessing stem cell-like memory T cells for adoptive cell transfer therapy of cancer --
9 T cell blockade- anti-CTLA4 immunotherapy against cancer and Abscopal effect in combination therapy --
10 T cell modulation- anti-OD-1 antibodies for the treatment of cancer --
11 T cell based therapies in combination with other procedures --
12 Chimeric antigen receptor T cells CD19 CAR --
13 Hematopoietic Stem Cell transplantation as immune therapy of malignancies.
Series Title: Cancer drug discovery and development.
Responsibility: Paolo A. Ascierto, David F. Stroncek, Ena Wang, editors.

Abstract:

Specific attention is devoted to the genetic manipulation of T cells through the introduction of re-directed T cell receptors, chimeric antibody receptors, and other genetic manipulation aimed at  Read more...

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