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|All Authors / Contributors:||
Aude Fayol; Jieping Zhu; Université de Paris-Sud. Faculté des Sciences d'Orsay (Essonne).
|Description:||357 p. : ill. ; 30 cm.|
|Responsibility:||Aude Fayol ; sous la direction de [Jieping Zhu].|
The scientific project consisted in developing new multi-components reactions (MCR) for the synthesis of polyheterocycles of very varied structures. For that, we emphasized the synthesis with three component of 5-amino-oxazoles developed by the laboratory starting from an aldehyde, an amine and a isocyanoacetamide. The use of the reactivity of this platform amino-oxazole and in particular its dienic character, made it possible to extend considerably the field of this new MCR. The introduction of a dienophile to one of the starting material made it possible to carry out an intramolecular reaction of cycloaddition. The variation of the nature and the site of the dienophile led to the synthesis of various polyheterocycies like : furoquinolines, tetrahydrofuropyridines, oxa-bridged tetrahydroquinolines, diazaphenanthrenes, tetrahydronaphthyridines, 6-azaindolines as well as tetrahydroquinolines.