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Dexmedetomidine for sedation of patients in the ICU or PICU : review of clinical effectiveness and safety

Author: Canadian Agency for Drugs and Technologies in Health,
Publisher: Ottawa (ON) : Canadian Agency for Drugs and Technologies in Health, January 2014.
Series: Rapid response report (Canadian Agency for Drugs and Technologies in Health)
Edition/Format:   eBook : Document : National government publication : English
Summary:
Sedation of ICU patients is often essential for ICU patients to maximize survival, reduce ICU and hospital stay, and facilitate mechanical ventilation. The standard of care for sedation include benzodiazepine sedatives and propofol. Some drawbacks of the available sedative agents include patients' agitation and delirium. To overcome these drawbacks, it has been suggested that dexmedetomidine can be an appropriate  Read more...
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Details

Genre/Form: Review
Material Type: Document, Government publication, National government publication, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Canadian Agency for Drugs and Technologies in Health,
OCLC Number: 879769289
Notes: Title from PDF caption title.
"CADTH Rapid Response Service."
"16 January 2014."
Description: 1 online resource (1 PDF file (21 pages)) : illustrations.
Series Title: Rapid response report (Canadian Agency for Drugs and Technologies in Health)
Responsibility: prepared by Canadian Agency for Drugs and Technologies in Health.

Abstract:

Sedation of ICU patients is often essential for ICU patients to maximize survival, reduce ICU and hospital stay, and facilitate mechanical ventilation. The standard of care for sedation include benzodiazepine sedatives and propofol. Some drawbacks of the available sedative agents include patients' agitation and delirium. To overcome these drawbacks, it has been suggested that dexmedetomidine can be an appropriate alternative to traditional sedatives for maintaining light to moderate sedation. However, the Health Canada approved label for dexmedetomidine provides warnings that the drug is associated with hypotension, clinically significant episodes of bradycardia, and sinus arrest. The objective of the current review is to evaluate the evidence surrounding the use of dexmedetomidine for sedation in intensive-care units.

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