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DHEA and the brain

Author: Robert Morfin
Publisher: London ; New York : Taylor & Francis, 2002.
Series: Nutrition, brain, and behavior, v. 1.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
In this book the authors evaluate existing studies and discuss new ideas and approaches to future investigations into the physiological actions of this hormone.
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Genre/Form: Electronic books
Additional Physical Format: Print version:
DHEA and the brain.
London ; New York : Taylor & Francis, 2002
(OCoLC)50285853
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Robert Morfin
ISBN: 0203301218 9780203301210 1280022019 9781280022012
OCLC Number: 54480681
Description: 1 online resource (xiv, 204 pages) : illustrations.
Contents: Cover --
Nutrition, brain and behaviour --
DHEA and the Brain --
Contents --
Contributors --
Series preface --
Preface --
Chapter 1 The brain, a putative source and target of DHEA --
NEUROSTEROID: THE CONCEPT AND ITS IMPLICATIONS --
REGULATION OF PREGNENOLONE AND DHEA, SYNTHESIS/ACCUMULATION IN RAT BRAIN TISSUE --
DHEA IN HUMANS --
CONCLUDING REMARKS --
REFERENCES --
Chapter 2 DHEA metabolites during the life span --
INTRODUCTION --
DHEA/S DURING LIFE AND THE IMPORTANCE OF STEROID SULFATASE --
DHEA METABOLISM --
7-OXYGENATED DHEA METABOLITES --
PHYSIOLOGICAL LEVELS OF 7-OH-DHEA ISOMERS AND AGEING --
7-OXO-DHEA --
16-HYDROXYLATED METABOLITES OF DHEA --
ACKNOWLEDGMENT --
REFERENCES --
Chapter 3 Postulated roles of DHEA in the decline of neural function with age --
INTRODUCTION --
THE LIFE HISTORY OF DHEA --
DHEA AS A NEUROSTEROID --
MEASURING DHEA IN THE BLOOD, BRAIN AND SALIVA --
DHEA: EXPERIMENTAL EFFECTS ON BEHAVIOR --
DHEA AND CORTISOL --
DHEA AND BRAIN FUNCTION IN MAN --
CONCLUSION --
ACKNOWLEDGMENTS --
REFERENCES --
Chapter 4 DHEA: hormone of youth and resilience --
still a maverick --
INTRODUCTION: THE NEUROSTEROIDS --
DHEAS AS EXCITATORY NEUROMODULATOR --
DHEA AS HORMONE OF MENTAL HEALTH --
DHEA(S) IN MEMORY AND AGEING --
DHEA/S AND SEXUAL DIMORPHISM --
DHEA/S REPLACEMENT --
CONCLUSION --
REFERENCES --
Chapter 5 DHEA effects on liver --
INTRODUCTION --
PHARMACOKINETICS, UPTAKE AND METABOLISM OF DHEA(S) --
ALTERATIONS IN ENERGY METABOLISM --
PEROXISOME PROLIFERATION --
OXIDATIVE STRESS AND LIPID PEROXIDATION --
HEPATOCARCINOGENIC EFFECT OF DHEA --
MODULATION OF HEPATOCARCINOGENESIS BY DHEA --
ANTICARCINOGENIC EFFECT OF DHEA --
CONCLUSION --
REFERENCES --
Chapter 6 DHEA and brain development --
DEFINITION OF A NEUROSTEROID --
ENZYMES INVOLVED IN THE SYNTHESIS OF DHEA --
DISTRIBUTION OF P450scc AND P450c17 IN THE BRAIN AND REGULATION OF THEIR EXPRESSION DURING DEVELOPMENT --
DEVELOPMENTAL ROLE OF DHEA AND DHEAS IN ORGANOGENESIS --
ACKNOWLEDGMENTS --
REFERENCES --
Chapter 7 DHEA metabolism in the brain: production and effects of the 7a-hydroxylated derivative --
INTRODUCTION --
7a-HYDROXYLATION OF DHEA IN MOUSE, RAT AND HUMAN BRAIN --
INVOLVEMENT OF CYP7B1 IN BRAIN --
ROLE OF P450 7B1 AND SUBSTRATE SPECIFICITY --
CYP7B1 IN HUMAN HIPPOCAMPUS --
NEUROPROTECTION AND P450 7B1 ACTIVITY --
CONCLUDING REMARKS --
ACKNOWLEDGMENT --
REFERENCES --
Chapter 8 DHEA: biosynthesis, regulation and function in the central nervous system --
INTRODUCTION --
DHEA --
BIOSYNTHESIS OF DHEA --
DHEA IN NORMAL AND PATHOLOGICAL BRAIN FUNCTION --
CONCLUSION --
ACKNOWLEDGMENTS --
REFERENCES --
Chapter 9 Cross-talk between DHEA and neuropeptides --
INTRODUCTION --
PEPTIDES MODULATING DHEA/DHEAS SYNTHESIS --
DHEA/DHEAS AND APPETITE MODULATING PEPTIDES --
DHEA/DHEAS, PEPTIDES, AND CALORIC INTAKE --
SEARCH FOR A LINK --
REFERENCES --
Chapter 10 DHEA effects on human behavior and psychiatric illness --
INTRODUCTION --
ASSOCIATION BETWEEN DHEA/S LEVEL AND MOOD, COGNITION, AND FUNCTIONAL ABILITIES IN NORMAL INDIVIDUALS --
BEHAVIORAL EFFECTS OF DHEA ADMINISTRATION IN NORMAL INDIVIDUALS --
tid.
Series Title: Nutrition, brain, and behavior, v. 1.
Responsibility: edited by Robert Morfin.
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Abstract:

In this book the authors evaluate existing studies and discuss new ideas and approaches to future investigations into the physiological actions of this hormone.

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