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Diagnostic and therapeutic antibodies

Author: Andrew J T George; Catherine E Urch
Publisher: Totowa, N.J. : Humana Press, ©2000.
Series: Methods in molecular medicine, 40.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
The use of monoclonal antibodies in treating disease has long held tantalizing promise, and the recent explosion of successful clinical trials-leading to the licensing of novel antibody-based therapeutic agents-has clearly demonstrated the power of recombinant antibody engineering, and greatly rejuvenated interest in their emergent clinical applications. In Diagnostic and Therapeutic Antibodies, a team of experts  Read more...
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Genre/Form: Electronic books
Gidsen (vorm)
Additional Physical Format: Diagnostic and therapeutic antibodies
(DLC) 99036821
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Andrew J T George; Catherine E Urch
ISBN: 0585418780 9780585418780
OCLC Number: 50493382
Reproduction Notes: Electronic reproduction. [S.l.] : HathiTrust Digital Library, 2010. MiAaHDL
Description: 1 online resource (xiv, 477 pages) : illustrations.
Details: Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Contents: pt. 1. Introduction --
The antibody molecule / Andrew J.T. George --
Polyclonal and monoclonal antibodies / Mary A. Ritter --
Engineering antibody molecules / Rakesh Verma --
Phage display technology / Michael Johns --
pt. 2. Antibodies in medicine --
Prospects for the application of antibodies in medicine / Herman Waldmann --
Antibodies for neoplastic disease: solid tumors / Ian T.W. Matthews --
The application of monoclonal antibodies in the treatment of lymphoma / Martin J. Glennie --
Antibodies for inflammatory disease: effector cells / Richard Smith --
Antibodies for inflammatory disease: cytokines / Peter C. Taylor --
Antibodies for transplantation / Denise L. Faustman --
Antibody-based therapies in infectious diseases / H. Barbaros Oral --
Antibodies in nuclear medicine / A. Michael Peters --
Animal models for tumor localization / Gail Rowlinson-Busza --
Antibodies for immunoassays / David J. Newman --
pt. 3. Ethics and industry --
Intellectual property / William M. Brown --
From laboratory to clinic: the story of CAMPATH-1 / Geoff Hale --
pt. 4. Production and purification --
Production of monoclonal antibodies / Jóna Freysdóttir --
Purification of monoclonal antibodies using protein A/G / Bridget Heelan --
Preparation of monoclonal antibodies using ion exchange chromatography / Maureen Power --
Quality control of raw materials / Patrick Harrison --
Cell banks and stability of antibody production / Pru Bird --
Measurement of endotoxin / Jenny Phillips --
Aseptic vial filling / Kuldip Bhamra --
Measurement of antibody concentrations by hemagglutination / Jenny Phillips --
pt. 5. Clinical application of antibodies --
Enzymatic digestion of monoclonal antibodies / Sarah M. Andrew --
How to make bispecific antibodies / Ruth R. French --
Radiolabeling of monoclonal antibodies / Calvin S.R. Gooden --
Determination of the immunoreactivity of radiolabeled monoclonal antibodies / Gail Rowlinson-Busza --
Use of biosensors to measure the kinetics of antibody-antigen interactions / Andrew J.T. George --
pt. 6. Application of antibodies in vitro --
How to set up an ELISA / Bill Jordan --
Measurement of HAMA and anti-idiotypic antibodies / Steve Nicholson --
SDS-PAGE and Western blotting / Abdulhamid A. Al-Tubuly --
Flow cytometric analysis / Paul F. McKay --
Immunocytochemistry / Susan Van Noorden --
Immunolabeling for electron microscopy / Catherine E. Sarraf --
pt. 7. Antibody engineering --
PCR of the V region / Rakesh Verma --
Phage display technology: protocols / Michael Johns.
Series Title: Methods in molecular medicine, 40.
Responsibility: edited by Andrew J.T. George and Catherine E. Urch.

Abstract:

Soon after the first description of monoclonal antibodies in 1976, there was enormous interest in the clinical application of antibodies, especially in the context of cancer.  Read more...

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"...a welcome addition to the clinician's medical library....written by experts in the field and cover a broad selection of issues, ranging from the basic structure of antibodies to intellectual Read more...

 
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