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Dictyostelids : Evolution, Genomics and Cell Biology.

Author: Maria Romeralo; Sandra Baldauf; Ricardo Escalante
Publisher: Dordrecht : Springer, 2013.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Since their discovery in 1869, the dictyostelids have attracted the attention of scientists in a wide variety of fields. This interest has stemmed from their peculiar lifestyle and developmental properties, which were shaped by the evolutionary forces that generated multicellularity during eukaryotic evolution. More recently, the dictyostelids have gained attention due to the striking similarities found at the  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Romeralo, Maria.
Dictyostelids : Evolution, Genomics and Cell Biology.
Dordrecht : Springer, ©2013
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Maria Romeralo; Sandra Baldauf; Ricardo Escalante
ISBN: 9783642384875 3642384870
OCLC Number: 858764175
Notes: 6 ... Conclusions and Future Perspectives.
Description: 1 online resource (259 pages)
Contents: Preface; Contents; 1 Dictyostelium discoideum as a Model in Biomedical Research; Abstract; 1 ... Introduction; 2 ... What Makes Social Amoebas Different?; 3 ... From the Soil to the Laboratory: The Early Times of D. Discoideum Research; 4 ... The Advent of Molecular Genetics Propelled D. discoideum into the Post-genomic Era; 5 ... A New Frontier in D. discoideum Research: Modeling Human Disease; 5.1 Pathogen --
Host Interactions in D. discoideum; 5.2 Pathobiology of Cell Motility and Chemotaxis; 5.3 Autophagy and Protein Aggregation Disorders; 5.4 The D. dictyostelium Model of Mitochondrial Disease. 5.5 Molecular Pharmacology in D. dictyostelium6 ... Concluding Remarks; Acknowledgments; References; 2 Genome Analysis of Social Amoebae; Abstract; 1 ... Genomics; 2 ... Nuclear Genomes of Social Amoebae; 2.1 The Model Organism D. discoideum; 2.2 Comparative Sequencing of Other Social Amoebae; 3 ... Plasmids, rDNA Palindrome, and Mitochondrial Genomes; 3.1 Plasmids; 3.2 rDNA Palindromes; 3.3 Mitochondria; 4 ... Regulation of Transcription on a Global Scale; 5 ... Curation of Genomes and Databases; 6 ... Future Directions of Genomics in Social Amoebae; References; 3 Signalling During Dictyostelium Development; Abstract. 1 ... Introduction2 ... Cell Movement and Signalling to the Cytoskeleton; 3 ... Cellular Behaviours During Chemotaxis; 4 ... Signalling During Chemotaxis; 5 ... Cell --
Cell Signalling Controlling Cell Movement During Multicellular Development; 6 ... Aggregation; 7 ... Mound and Slug Formation; 8 ... Differentiation; Acknowledgments; References; 4 The Chemotactic Compass; Abstract; 1 ... Chemotaxis; 2 ... Dictyostelium as Model System for Chemotaxis; 3 ... cAMP and Folic Acid; 4 ... The Dictyostelium cAMP Receptors; 5 ... cAR Structure and Localization; 6 ... Signaling After Receptor Activation. 7 ... Temporal Responses to Chemoattractants Provide Valuable Spatial Information8 ... The Role of Polarity in Migration; 9 ... Dictyostelium Heterotrimeric G Proteins and Functions; References; 5 Transcriptional Regulators: Dynamic Drivers of Multicellular Formation, Cell Differentiation and Development; Abstract; 1 ... Introduction; 2 ... Entering Development; 3 ... Multicellular Assembly; 4 ... Culmination and Fruiting Body Formation; 5 ... Open Questions and Future Directions; References; 6 Non-coding RNAs in Dictyostelium discoideum and Other Dictyostelid Social Amoebae; Abstract; 1 ... Introduction. 2 ... lncRNAs as Developmental Regulators3 ... Medium-Sized ncRNAs; 3.1 Class I RNAs are Involved in Development and Conserved Throughout Dictyostelia; 3.2 Spliceosomal RNAs with Unexpected Features; 3.3 snoRNAs: Modifiers of RNA; 3.4 Non-coding RNAs with Functions in Protein Delivery and RNA Processing; 3.5 Medium-Sized ncRNAs with Unknown Functions:Specific to D. discoideum?; 4 ... Small RNAs: Important Regulators of Gene Expression; 4.1 Abundant Small Interfering RNAs Derived from the Transposon DIRS-1; 4.2 MicroRNAs in D. discoideum; 5 ... Conserved ncRNA Gene Promoter Element?

Abstract:

Since their discovery in 1869, the dictyostelids have attracted the attention of scientists in a wide variety of fields. This interest has stemmed from their peculiar lifestyle and developmental properties, which were shaped by the evolutionary forces that generated multicellularity during eukaryotic evolution. More recently, the dictyostelids have gained attention due to the striking similarities found at the genomic, cellular and biochemical levels with human cells, which has propelled the species Dictyostelium discoideum to become a model system for biology and medicine in many laboratories.

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