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Disordered vertebral and rib morphology in pudgy mice : structural relationships to human congenital scoliosis

Author: Frederic Shapiro
Publisher: Switzerland : Springer Science and Business Media : Springer, [2016]
Series: Advances in anatomy, embryology, and cell biology, 221.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse  Read more...
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Genre/Form: Electronic books
Additional Physical Format: (OCoLC)952981232
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Frederic Shapiro
ISBN: 9783319431512 331943151X
OCLC Number: 958984228
Description: 1 online resource.
Contents: Abstract; Contents; Chapter 1: Introduction; Chapter 2: Materials and Methods; 2.1 Source, Distribution, and Ages of Pudgy and Non-affected Mice; 2.2 Whole Mount Preparations; 2.3 Radiographic Studies; 2.4 Histologic Studies; 2.4.1 Serial Sections; 2.5 Computerized Three-Dimensional Reconstructions; 2.6 Previous Studies on Chick Vertebral Development and Human Congenital Scoliosis; Chapter 3: Results; 3.1 Gross Appearance; 3.2 Whole Mount Appearances; 3.2.1 Overview; 3.2.1.1 Normal Development; Newborn; Eight Days; Three and Four Weeks; 3.2.1.2 Pudgy Mouse Development; Newborn Eight and Nine DaysThree Weeks; Four Weeks; 3.3 Radiographic Studies; 3.3.1 Overview; 3.3.1.1 Normal Development (Non-affected pu/+ Mice); Newborn [#s 18, 25, 53]; One Day [#21]; Three Days [#49]; Nine Days [#14]; Three Weeks [#s 11, 26, 28]; Four Weeks [#38]; Six Weeks [#12]; Two Months [#3]; 3.3.1.2 Pudgy Mouse Development (pu/pu Mice); Overview; Findings in Vertebral/Rib Patterns Within Sibling Groups; Sibling Group 1 [#s 2, 4, and 5, Two Months]; Sibling Group 2 [#10, Three Weeks and #13, Six Weeks] #10; Sibling Group 3 [#19, Newborn and #20, One Day] Sibling Group 4 [#s 27 and 29, Three Weeks]Sibling Group 5 [#s 35 and 36, Four Weeks]; Sibling Group 6 [#s 50 and 51, Three Days]; Sibling Group 7 [#s 52 and 54, Newborn]; 3.4 Histology Studies: Vertebrae, Ribs, Intervertebral Discs, and Ganglia; 3.4.1 Overview; 3.4.2 Serial Section Assessments; 3.4.2.1 Development of Vertebrae; Normal Vertebral Body and Intervertebral Disc Development; Pu/+ 63, Embryo; Pu/+ 25, Newborn; Pu/+ 18, Newborn; Pu/+ 21, One Day; Pu/+ 49, Three Days; Pu/+ 44, Six Days; Pu/+ 14, Nine Days; Pu/+ 11, 26, 28, Three Weeks; Pu/+ 38, Four Weeks; Pu/+ 12, Six Weeks Pudgy Mouse Vertebral and Intervertebral Disc DevelopmentOverview; 3.4.2.2 Development of Ribs; Normal Rib Development (pu/+); Pudgy Rib Development (pu/pu); 3.4.2.3 Development of Ganglia; Normal Ganglia Formation (pu/+); Pudgy Mouse Ganglia Formation (pu/pu); 3.4.2.4 Development of Intervertebral Discs; Normal Intervertebral Disc Formation (pu/+); Pudgy Intervertebral Disc Formation (pu/pu); 3.5 Computerized Three-Dimensional Reconstructions of Histologic Sections; 3.6 Chick Embryo Vertebral Development (Previous Studies) 3.7 Radiology and Histopathology of Human Congenital Scoliosis of the Spine (With Normal Comparisons)3.7.1 Normal Fetal and Neonatal Human Vertebral Bodies; 3.7.2 Congenital Scoliosis of the Spine; 3.7.2.1 Radiologic Appearance; 3.7.2.2 Histopathology; Variation in Tissue Structure at the Same Level as Demonstrated in Serial Sections; Chapter 4: Discussion; 4.1 Normal Mouse Vertebral Development Compared to Pudgy Mouse Vertebral Development: General Considerations; 4.2 The Study of Vertebral/Axial Development Showing Histologic and Molecular Progression
Series Title: Advances in anatomy, embryology, and cell biology, 221.
Responsibility: Frederic Shapiro.
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Abstract:

This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.

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