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DNA alterations in Lynch Syndrome : advances in molecular diagnosis and genetic counselling

著者: Matjaž Vogelsang
出版商: Dordrecht ; New York : Springer, ©2013.
版本/格式:   电子图书 : 文献 : 英语查看所有的版本和格式
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提要:
Lynch syndrome (LS) is the most common cause of inherited colorectal cancer, a disease with a high mortality rate. An estimated 37,000 of diagnosed colorectal cancer cases worldwide are attributed to Lynch syndrome each year. Intensive cancer screening, with early initiation and frequent follow-up, can reduce colorectal cancer incidence and mortality in LS patients. This book provides an up-to-date overview on the  再读一些...
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类型/形式: Electronic books
材料类型: 文献, 互联网资源
文件类型: 互联网资源, 计算机文档
所有的著者/提供者: Matjaž Vogelsang
ISBN: 9789400765979 9400765975
OCLC号码: 843753219
描述: 1 online resource.
内容: Historical Development of Lynch Syndrome / Henry T. Lynch, Stephen J. Lanspa, Carrie L. Snyder --
Molecular Mechanisms and Functions of DNA Mismatch Repair / Hui Geng, Peggy Hsieh --
New Insights into Lynch Syndrome Diagnosis / Emile Coetzee, Ursula Algar, Paul Goldberg --
Genetic Testing, an Optimal Strategy for Lynch Syndrome Identification / Petra Hudler --
Functional Analyses Help to Assess the Pathogenicity of MMR Gene Variants of Uncertain Significance / Minna Nyström, Minttu Kansikas --
The Role of Epimutations of the Mismatch Repair Genes in the Development of Lynch Syndrome Related Cancers / Megan P. Hitchins --
Mutations in Non-MMR Genes Modifying or Mimicking Lynch Syndrome Phenotype / Mala Pande, Jinyun Chen, Chongjuan Wei, Yu-Jing Huang --
Lynch Syndrome: Genetic Counselling of At-Risk Individuals and Families / Zandrè Bruwer, Raj Ramesar.
责任: Matjaž Vogelsang, editor.
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This book surveys the genetic and epigenetic basis of Lynch syndrome, evaluating its clinical features and analyzing molecular tools for identifying mutations responsible for the syndrome; includes  再读一些...

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From the reviews: "This highly specialized book is an extensive, multiauthored discussion of Lynch syndrome. ... From health professionals implementing general health surveillance to oncologists and 再读一些...

 
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