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DNA engineered noble metal nanoparticles : fundamentals and state-of-the-art-of nanobiotechnology

Author: Ignác Capek
Publisher: Hoboken, New Jersey : John Wiley and Sons, Inc. ; Salem, Massachusetts : Scrivener Publishing LLC, 2015.
Series: Advanced materials series (Scrivener Publishing)
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
There is a growing interest in the use of nanoparticles modified with DNAs, viruses, peptides and proteins for the rational design of nanostructured functional materials and their use in biosensor applications. The challenge is to control the organization of biomolecules on nanoparticles while retaining their biological activity as potential chemical and gene therapeutics. These noble metal  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Capek, Ignác.
DNA engineered noble metal nanoparticles.
Hoboken, New Jersey : John Wiley and Sons, Inc. ; Salem, Massachusetts : Scrivener Publishing LLC, 2015
(DLC) 2015007814
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Ignác Capek
ISBN: 9781119120926 1119120926 9781119120933 1119120934 9781119120940 1119120942 1118072146 9781118072141
OCLC Number: 904400172
Description: 1 online resource.
Contents: Nucleic acids --
Noble metal nanoparticles --
DNA-based conjugates --
DNA-noble metal nanoparticle conjugates --
DNA-gold nanoparticle conjugates --
PNA-noble metal nanoparticles conjugates --
DNA-silver nanoparticles conjugates --
The structure of DNA-noble metal nanoparticles conjugates --
Photochemical and photophysical events --
Nanoparticle therapeutics.
Series Title: Advanced materials series (Scrivener Publishing)
Responsibility: Ignác Capek.

Abstract:

There is a growing interest in the use of nanoparticles modified with DNAs, viruses, peptides and proteins for the rational design of nanostructured functional materials and their use in biosensor applications. The challenge is to control the organization of biomolecules on nanoparticles while retaining their biological activity as potential chemical and gene therapeutics. These noble metal nanoparticles/biomolecules conjugates have specific properties and therefore they are attractive materials for nanotechnology in biochemistry and medicine. In this book, the author review work performed dealing with the DNA structure and functionalities, interactions between DNA, noble metal nanoparticles, surface active agents, solvents and other additives. Particular attention is given to how the DNA's chain length and the DNA conformation affect the interaction and structure of the nanoconjugates and nanostructures that are formed. Also discussed are the recent advances in the preparation, characterization, and applications of noble metal nanoparticles that are conjugated with DNA aptamers and oligomers. The advantages and disadvantages of functionalized nanoparticles through various detection modes are highlighted, including colorimetry, fluorescence, electrochemistry, SPR, and, mass spectrometry for the detection of small molecules and biomolecules. The functionalized noble metal nanoparticles are selective and sensitive for the analytes, showing their great potential in biosensing. Furthermore, this book reviews recent progress in the area of DNA-noble metal nanoparticles based artificial nanostructures, that is, the preparation, collective properties, and applications of various DNA-based nanostructures are also described.

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