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DNA repair in cancer therapy : molecular targets and clinical applications

Author: Mark Richard Kelley
Publisher: Amsterdam ; Boston : Academic Press, 2012.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Cancer therapeutics include an ever-increasing array of tools at the disposal of clinicians in their treatment of this disease. However, cancer is a tough opponent in this battle, and current treatments, which typically include radiotherapy, chemotherapy and surgery, are not often enough to rid the patient of his or her cancer. Cancer cells can become resistant to the treatments directed at them, and overcoming this  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
DNA repair in cancer therapy.
Amstrerdam : Boston : Elsevier/Academic Press, 2012
(OCoLC)711573687
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Mark Richard Kelley
ISBN: 0123850002 9780123850003
OCLC Number: 749875989
Description: 1 online resource (xiii, 316 pages)
Contents: Introduction and Overview of Current Targets: Bench to Clinic / Mark R. Kelley --
2. MGMT a Critical DNA Repair Gene Target for Chemotherapy Resistance / Stanton L. Gerson and Lili Liu --
3. Blockade of Base Excision Repair: Inhibitionof Small Lesions Results in Big Consequences to Cancer Cells / Melissa Fishel and Carlo Vascotto --
4. PARP Inhibitors --
Scientific Rationale and Clinical Development for Cancer / Ruth Plummer, Nicola J. Curtin and Yvette Drew --
5. Inhibiting Selective DNA Polymerases for Therapeutic Intervention / Anthony J. Berdis --
6. Targeting the Nucleotide Excision Repair Pathway for Therapeutic Applications / John Turchi and Stephan M. Patrick --
7. Homologous Recombination and ATM/ATR Targets / Henning Willers, Lee Zou and Heike N. Pfaffle --
8. DNA Double Strand Break Repair by Nonhomologous End Joining and its Clinical Relevance / Michael Weinfeld and Susan Lees-Miller --
9. Defective MMR-c-Abl-p73-GADD45alpha Expression in Cancer Chemoresistance / David Boothman and Long Shan Li --
10. DNA Repair Signaling Targets / Susan Ashwell --
11. Redox Regulation of DNA Repair and Therapeutic / Millie M. Georgiadis --
12. Personalized Cancer Medicine: DNA Repair Alterations is a Promising Predictive Marker in Cancer / Srinivasan Madhusudan --
13. The Role of DNA Damage and Repair in Neurotoxicity Caused by Cancer Therapies / Michael R. Vasko --
14. Future Directions / Mark R. Kelley.
Responsibility: edited by Mark Kelley.

Abstract:

Cancer therapeutics include an array of tools at the disposal of clinicians in their treatment of this disease. This title focuses on the translational and clinical use of DNA repair as a target area  Read more...

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"This volume, orchestrated by Mark R. Kelley from Indiana University, offers 14 chapters by acknowledged experts that address the particular relationship between DNA repair and cancer. The content of Read more...

 
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