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DNA repair of cancer stem cells

Author: Lesley A Mathews; Stephanie M Cabarcas; Elaine M Hurt
Publisher: Dordrecht ; New York : Springer, ©2013.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
The existence of 'cancer stem cells' (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Lesley A Mathews; Stephanie M Cabarcas; Elaine M Hurt
ISBN: 9789400745902 9400745907 9400745893 9789400745896
OCLC Number: 803422561
Description: 1 online resource.
Contents: Introduction to Cancer Stem Cells / Chengzhuo Gao, Robert E. Hollingsworth and Elaine M. Hurt --
DNA Repair Pathways and Mechanisms / Thomas S. Dexheimer --
Resistance and DNA Repair Mechanisms of Cancer Stem Cells: Potential Molecular Targets for Therapy / Aamir Ahmad, Yiwei Li, Bin Bao and Fazlul H. Sarkar --
DNA Repair in Normal Stem Cells / Olga Momčilović and Gerald Schatten --
DNA Repair Mechanisms in Glioblastoma Cancer Stem Cells / Monica Venere, Jeremy N. Rich and Shideng Bao --
DNA Repair Mechanisms in Breast Cancer Stem Cells / Hong Yin and Jonathan Glass --
DNA Repair Mechanisms in Other Cancer Stem Cell Models / Mihoko Kai --
Pancreatic Cancer Stem Cells in Tumor Progression, Metastasis, Epithelial-Mesenchymal Transition and DNA Repair / Nagaraj S. Nagathihalli and Erika T. Brown --
Targeting Cancer Stem Cell Efficient DNA Repair Pathways: Screening for New Therapeutics / Lesley A.
Responsibility: Lesley A. Mathews, Stephanie M. Cabarcas, Elaine M. Hurt, editors.
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Abstract:

Therapies targeting cancer stem cells are set for a bright medical future. The first volume to focus on the DNA repair mechanisms of both normal and cancer stem cells, this guide is a vital aid to  Read more...

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schema:description"The existence of 'cancer stem cells' (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise. To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types."
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