Find a copy online
Links to this item
Find a copy in the library
Finding libraries that hold this item...
|Additional Physical Format:||Print version:
Mathews, Lesley A.
DNA Repair of Cancer Stem Cells
Dordrecht : Springer,c2012
|Material Type:||Document, Internet resource|
|Document Type:||Internet Resource, Computer File|
|All Authors / Contributors:||
Lesley A Mathews; Stephanie M Cabarcas; Elaine M Hurt
|Notes:||Description based upon print version of record.
6.3.3 PTEN/AKT/WNT/b-Catenin and DNA Damage Response in Normal and Tumorous Mammary Stem Cells
|Description:||1 online resource (179 p.)|
|Contents:||Preface; Contents; Chapter 1 Introduction to Cancer Stem Cells; 1.1 The Etiology of Cancer; 1.2 The Cancer Stem Cell Hypothesis; 1.3 Properties and Cell of Origin of CSCs; 1.4 Isolation of CSCs; 1.4.1 Side Populations; 1.4.2 Surface Markers; 1.4.3 Nonadherent Sphere Culture; 1.4.4 ALDH Activity; 1.5 Implications of the CSC Hypothesis for Cancer Treatment; 1.6 Concluding Remarks; References; Chapter 2 DNA Repair Pathways and Mechanisms; 2.1 Overview; 2.2 Types of DNA Damage; 2.3 DNA Repair Mechanisms; 2.3.1 Base Excision Repair (BER); 2.3.2 Mismatch Repair (MMR) 2.3.3 Nucleotide Excision Repair (NER)2.3.4 Double-Strand Break Repair; 188.8.131.52 Homologous Recombination (HR); 184.108.40.206 Non-Homologous End-Joining (NHEJ); 2.4 Conclusion; References; Chapter 3 Resistance and DNA Repair Mechanisms of Cancer Stem Cells; 3.1 Introduction; 3.2 CSCs and Relevant Cell Signaling Pathways; 3.3 How Do CSCs Manage to Survive?; 3.3.1 Quiescence; 3.3.2 Up-Regulation of ABC Transporters; 3.3.3 Resistance to Irradiation; 3.3.4 DNA Damage-Repair in CSCs; 220.127.116.11 DNA Repair and Drug Resistance in Cancer and CSCs; 18.104.22.168 Enhanced DNA Repair in CSCs 3.4 Targeting CSCs with Natural Compounds3.5 Conclusions and Perspectives; References; Chapter 4 DNA Repair in Normal Stem Cells; 4.1 Introduction; 4.2 Stem Cells; 4.2.1 Pluripotent Stem Cells; 4.2.2 Multipotent Stem Cells; 4.3 DNA Damage in Stem Cells; 4.3.1 DNA Repair in Pluripotent Stem Cells; 22.214.171.124 Double Strand Break Repair; 126.96.36.199 Nucleotide Excision Repair; 188.8.131.52 Base Excision Repair; 184.108.40.206 Mismatch Repair; 220.127.116.11 Genomic Integrity in Induced Pluripotent Stem Cells; 4.3.2 DNA Damage Responses in Multipotent Stem Cells; 4.4 Conclusions; References Chapter 5 DNA Repair Mechanisms in Glioblastoma Cancer Stem Cells5.1 Introduction; 5.2 Enrichment of Glioma Stem Cells; 5.3 Functional Validation of Glioma Stem Cells; 5.4 Response of Glioma Stem Cells to Current Therapies Targeting the DNA Damage Response; 5.5 Role of the Microenvironment on the Response of Glioma Stem Cells to DNA Damage; 5.6 DNA Repair and Checkpoint Activation in Glioma Stem Cells; 5.6.1 Base Excision Repair and Nucleotide Excision Repair; 5.6.2 Mismatch Repair; 5.6.3 Homologous Recombination and Non-Homologous End Joining; 5.6.4 Checkpoint Activation in Glioma Stem Cells 5.7 Future DirectionsReferences; Chapter 6 DNA Repair Mechanisms in Breast Cancer Stem Cells; 6.1 Breast Cancer Stem Cells: Identification, Maintenance, Enrichment, and Clinical Significance; 6.1.1 Identification of Breast Cancer Stem Cells; 6.1.2 The Origin of BCSC; 6.1.3 Maintenance of Self-Renewal in BCSC; 6.2 Treatment Resistance and DNA Repair in BCSC; 6.2.1 Treatment Resistance in BCSC; 6.2.2 Biological Features of BCSC for the Treatment Resistance; 6.3 DNA Repair Mechanisms of BCSC; 6.3.1 Homologous Recombination Plays Roles in BCSC; 6.3.2 Over-Active Checkpoint Response|