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DNA replication and human disease

Author: Melvin L DePamphilis
Publisher: Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press, ©2006.
Series: Cold Spring Harbor monograph series, 46.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
At least 5 trillion cell divisions are required for a fertilized egg to develop into an adult human, resulting in the production of more than 20 trillion meters of DNA! And yet, with only two exceptions, the genome is replicated once and only once each time a cell divides. How is this feat accomplished? What happens when errors occur? This book addresses these questions by presenting a thorough analysis of the  Read more...
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Genre/Form: Portrait
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Melvin L DePamphilis
ISBN: 0879697660 9780879697662
OCLC Number: 65195320
Description: xvii, 814 pages : illustrations (some color) ; 24 cm.
Contents: 1. Duplication of DNA in eukaryotic cells / Thomas J. Kelly and Bruce Stillman --
2. Eukaryotic DNA replication origins / Mirit I. Aladjem, Arturo Falaschi and David Kowalski --
3. Assembly of pre-replication complexes / Umasundari Sivaprasad, Anindya Dutta and Stephen P. Bell --
4. Activation of pre-replication complexes / Johannes C. Walter and Hiroyuki Araki --
5. Eukaryotic DNA replication forks / Peter M.J. Burgers and Yeon-Soo Seo --
6. Chromatin assembly / Paul D. Kaufman and Genevieve Almouzni --
7. Inheritance of genomic methylation patterns / Robert A. Rollins, Marc Damelin and Timothy H. Bestor --
8. Termination of DNA replication / Deepak Bastia and Bidyut K. Mohanty.
Series Title: Cold Spring Harbor monograph series, 46.
Responsibility: edited by Melvin L. DePamphilis.
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Abstract:

At least 5 trillion cell divisions are required for a fertilized egg to develop into an adult human, resulting in the production of more than 20 trillion meters of DNA! And yet, with only two exceptions, the genome is replicated once and only once each time a cell divides. How is this feat accomplished? What happens when errors occur? This book addresses these questions by presenting a thorough analysis of the molecular events that govern DNA replication in eukaryotic cells. The association between genome replication and cell proliferation, disease pathogenesis, and the development of targeted therapeutics is also addressed.

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